Radiosensitization by oxaliplatin in a mouse adenocarcinoma: Influence of treatment schedule
Radiosensitization by oxaliplatin in a mouse adenocarcinoma: Influence of treatment schedule
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DOI：
10.1016/s0360-3016(01)02792-4
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发表时间：
2002-03-15
影响因子：
7
通讯作者：
Danesi, DT
中科院分区：
文献类型：
--
作者：
Cividalli, A;Ceciarelli, F;Danesi, DT
目的：研究奥沙利铂（1-OHP）作为放射增敏剂在体内的应用。方法和材料：实验在小鼠（C3 D2 F1）进行，在一只脚上移植的乳腺癌。结果：1-OHP和CDDP分别以6和10 mg/kg体重的剂量单次给药。1-OHP或CDDP的给药产生显著的TGD，但仅在10 mg/kg的剂量下。以不同的顺序和时间间隔（1 h、4 h和24 h）进行单剂量X射线（10戈伊）和1-OHP（6和10 mg/kg）联合治疗。这些联合治疗的所有TGD在它们之间是均匀的（表明顺序和时间间隔不影响结果），并且不依赖于药物剂量。X射线（10和20戈伊）和1-OHP（6和10 mg/kg）联合处理时，TGD仅随X射线剂量增加而增加。对于分次实验，进行不同的1-OHP给药方案：每4天两次给药。选择毒性最小的方案（1-OHP总剂量为6至14 mg/kg）与每日10次2戈伊X射线治疗联合治疗。在1-OHP剂量为10至14 mg/kg的治疗中观察到明显的药物剂量-效应关系。结论：尽管低剂量1-OHP单独给药时不会诱导TGD，但在联合方案中，它可以增加X射线疗效。(C)2002年爱思唯尔科技有限公司
Purpose: The aim of our study was to investigate if oxaliplatin (1-OHP) could be used as a radiosensitizer in vivo. Methods and Materials: Experiments were performed in mice (C3D2F1) bearing a transplanted mammary carcinoma in a foot. Drugs, 1-OHP and cis-diammine-dichloro-platinum (CDDP), were administered i.p. Results were analyzed in terms of tumor growth delay (TGD).Results: 1-OHP and CDDP were tested in single doses of 6 and 10 mg/kg body weight. Administration of either 1-OHP or CDDP produced a significant TGD but only with the dose of 10 mg/kg. Single dose combined X-ray (10 Gy) and 1-OHP (6 and 10 mg/kg) treatments were performed with different sequences and time intervals (I h, 4 h, and 24 h). All TGDs of these combined treatments were uniform among themselves (indicating that sequence and time interval did not influence the results), and did not depend on the drug dose. In X-ray (10 and 20 Gy) and 1-OHP (6 and 10 mg/kg) combined treatment, the TGDs increased only with X-ray dose. Different 1-OHP administration schedules were performed for fractionated experiments: two treatments every 4 days. The least toxic protocol (1-OHP total dose from 6 to 14 mg/kg) was selected for combined treatments with 10 daily X-ray treatments of 2 Gy. A clear drug dose-effect relationship was observed in those treatments with 1-OHP doses from 10 to 14 mg/kg.Conclusions: Although low-dose 1-OHP did not induce a TGD when administered alone, in combined protocols it increased X-ray efficacy. (C) 2002 Elsevier Science Inc.