Role of transcription factors Brn-3.1 and Brn-3.2 in auditory and visual system development
Role of transcription factors Brn-3.1 and Brn-3.2 in auditory and visual system development
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DOI：
10.1038/381603a0
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发表时间：
1996-06-13
期刊：
影响因子：
64.8
通讯作者：
Rosenfeld, MG
中科院分区：
文献类型：
--
作者：
Erkman, L;McEvilly, RJ;Rosenfeld, MG
神经表达基因Brn-3.1和Brn-3.2（参考文献1-6）是秀丽隐杆线虫unc-86基因的哺乳动物同源基因(7)，与Brn-3.0（参考文献1-3,8,9）一起构成IV类po结构域转录因子（10），Brn-3.1和Brn-3.2提供了一种探索扩展基因家族在神经发育中潜在的独特生物学功能的方法。高度相关的Brn-3家族成员具有相似的dna结合偏好（1,2），并且在感觉神经系统、中脑和后脑中有重叠的表达模式（1-6,8,9），这表明功能冗余。在这里，我们报道了Brn-3.1和Brn-3.2对不同感觉神经细胞的终末分化进行了严格的调节，其中它们表现出选择性的空间和时间表达模式。定义不同的神经节细胞群，Brn-3.1突变导致完全耳聋，由于毛细胞在内耳中出现失败，随后耳蜗和前庭神经节丧失。
THE neurally expressed genes Brn-3.1 and Brn-3.2 (refs 1-6) are mammalian orthologues of the Caenorhabditis elegans unc-86 gene(7) that constitute, with Brn-3.0 (refs 1-3,8,9), the class IV POU-domain transcription factors(10), Brn-3.1 and Brn-3.2 provide a means of exploring the potentially distinct biological functions of expanded gene families in neural development, The highly related members of the Brn-3 family have similar DNA-binding preferences(1,2) and overlapping expression patterns in the sensory nervous system, midbrain and hindbrain(1-6,8,9), suggesting functional redundancy, Here we report that Brn-3.1 and Brn-3.2 critically modulate the terminal differentiation of distinct sensorineural cells in which they exhibit selective spatial and temporal expression patterns, Deletion of the Brn-3.2 gene causes the loss of most retinal ganglion cells, defining distinct ganglion cell populations, Mutation of Brn-3.1 results in complete deafness, owing to a failure of hair cells to appear in the inner ear, with subsequent loss of cochlear and vestibular ganglia.