Plasmodium falciparum stimuli for human gamma delta T cells are related to phosphorylated antigens of mycobacteria
Plasmodium falciparum stimuli for human gamma delta T cells are related to phosphorylated antigens of mycobacteria
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DOI：
10.1128/iai.64.8.2892-2896.1996
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发表时间：
1996-08-01
影响因子：
3.1
通讯作者：
Fournie, JJ
中科院分区：
文献类型：
--
作者：
Behr, C;Poupot, R;Fournie, JJ
多年来，人们已知道恶性疟原虫中存在主要人类血液 γ δ T 细胞亚群的有丝分裂因子。这些带有 T 细胞受体 V gamma 9 和 V delta 2 可变区的 γ δ T 细胞也通过识别几种磷酸化非肽抗原对结核分枝杆菌做出反应。在这项研究中，我们对疟疾刺激物进行了更好的表征，并表明恶性疟原虫裂殖体对 V gamma 9/V delta 2 gamma delta T 细胞的多克隆激活也完全归因于两种磷酸化疟疾化合物。在真核细胞中发现这种刺激物证明了不同的细胞内寄生虫之间存在抗原联系，例如疟原虫和分枝杆菌物种。因此，磷酸化抗原可能参与针对各种人类病原体的转病 T 细胞反应的常见模式。
The presence in Plasmodium falciparum of a mitogenic factor for the major human blood gamma delta T-cell subset has been known for years. These gamma delta T cells bearing T-cell receptor V gamma 9 and V delta 2 variable regions also respond to Mycobacterium tuberculosis, through recognition of several phosphorylated nonpeptidic antigens. In this study, we undertook a better characterization of the malarial stimulus and show that the polyclonal activation of V gamma 9/V delta 2 gamma delta T cells by P. falciparum schizonts is also and exclusively attributable to two phosphorylated malarial compounds. The finding of such stimuli in eukaryotic cells evidence an antigenic link between intracellular parasites as different as Plasmodium and Mycobacterium species. Hence, phosphorylated antigens could be involved in a common pattern of transdisease T-cell responses against various human pathogens.