Comorbid substance-use in schizophrenia: Relation to positive and negative symptoms
Comorbid substance-use in schizophrenia: Relation to positive and negative symptoms
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DOI：
10.1016/j.schres.2006.04.004
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发表时间：
2006-09-01
影响因子：
4.5
通讯作者：
Baldessarini, R. J.
中科院分区：
文献类型：
--
作者：
Talamo, A.;Centorrino, F.;Baldessarini, R. J.
由于物质使用障碍（SUD）在精神分裂症患者中很常见，我们检验了合并症患者（SUD[+]）比非合并症患者（SUD[-]）有更多阳性和阴性症状的假设。从文献检索中发现的报告中，我们使用荟萃分析方法比较了阳性和阴性综合征量表（PANSS）在患有和不患有SUD的精神分裂症患者中的评分。9组比较（N=725例）中，SUD患者多为男性，滥用酒精、大麻、可卡因。SUD[+]患者panss阳性评分明显高于对照组，panss阴性评分明显低于对照组。精神分裂症患者合并症SUD与男性相关，且PANSS阳性评分较高，阴性评分较低。因果关系仍有待澄清。(c) 2006 Elsevier B.V.版权所有
As substance use disorders (SUD) are common in schizophrenia patients, we tested the hypothesis that comorbid patients (SUD [+]) have more positive vs. negative symptoms than non-comorbid (SUD[-]) patients. From reports identified by literature-searching we compared Positive and Negative Syndrome Scale (PANSS) ratings in schizophrenia patients with and without SUD using meta-analytic methods. Among 9 comparisons (N=725 subjects), SUD[+] patients were more often men, and abused alcohol > cannabis > cocaine. SUD[+] patients had very significantly higher PANSS-positive, and lower PANSS-negative scores. Comorbid SUD in schizophrenia patients was associated with male sex and higher PANSS positive to lower negative scores. Cause-effect relationships remain to be clarified. (c) 2006 Elsevier B.V. All rights reserved.