Polymer control of ligand display on gold nanoparticles for multimodal switchable cell targeting
Polymer control of ligand display on gold nanoparticles for multimodal switchable cell targeting
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DOI：
10.1039/c1cc12654g
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发表时间：
2011-01-01
影响因子：
4.9
通讯作者：
Salmaso, Stefano
中科院分区：
文献类型：
--
作者：
Mastrotto, Francesca;Caliceti, Paolo;Salmaso, Stefano
细胞特异性配体在金纳米颗粒上的功能可以通过共接枝的热敏聚合物选择性地进行门控。在LCST以下，反应链延伸聚合物阻止细胞表面受体接近亲和配体，而在LCST以上，聚合物坍塌暴露配体并允许与受体结合，这反过来促进细胞内化。
The function of cell-specific ligands on gold nanoparticles can be selectively gated by the action of co-grafted thermosensitive polymers. Below the LCST the responsive chain-extended polymers prevent cell-surface receptors from accessing the affinity ligands while above the LCST, the polymers collapse exposing the ligands and allowing binding to receptors, which in turn promotes cell internalisation.