Four new C19 homolignans, schiarisanrins A, B, and D and cytotoxic schiarisanrin C, from Schizandra arisanensis
Four new C19 homolignans, schiarisanrins A, B, and D and cytotoxic schiarisanrin C, from Schizandra arisanensis
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DOI：
10.1021/jo9622542
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发表时间：
1997-05-16
影响因子：
3.6
通讯作者：
Chen, CF
中科院分区：
文献类型：
--
作者：
Kuo, YH;Kuo, LMY;Chen, CF
从北五味子中分离出四种新的具有 5,4'-丁醇-2,4-环己二烯酮-6-螺-3'-(2',3'-二氢苯并-[b]呋喃)骨架的 C-19 同木脂素：五味子素 A、五味子素 B、五味子素 D 和细胞毒性五味子素 C。它们的结构和立体化学已通过光谱和单晶 X 射线分析确定。 Schiarisanrin C 对鼻咽 KB 表皮样癌、COLO-205 结肠癌、HEPA 肝癌和 HELA 宫颈肿瘤细胞具有细胞毒活性，ED50 值分别为 0.36、7.1、4.9 和 5.7 μg/mL。
Four new C-19 homolignans with a 5,4'-butano-2,4-cyclohexadienone-6-spiro-3'-(2',3'-dihydrobenzo- [b]furan) skeleton, schiarisanrin A, schiarisanrin B, schiarisanrin D, and cytotoxic schiarisanrin C, were isolated from Schizandra arisanensis. Their structure and stereochemistry have been established by spectral and single-crystal X-ray analysis. Schiarisanrin C has cytotoxic activity with ED50 values of 0.36, 7.1, 4.9, and 5.7 mu g/mL, respectively, against KB epidermoid carcinoma of nasopharynx, COLO-205 colon carcinoma, HEPA hepatoma, and HELA cervix tumor cells.