Familial risks and temporal incidence trends of multiple myeloma
Familial risks and temporal incidence trends of multiple myeloma
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DOI：
10.1016/j.ejca.2005.11.033
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发表时间：
2006-07-01
影响因子：
8.4
通讯作者：
Hemminki, Kari
中科院分区：
文献类型：
--
作者：
Altieri, Andrea;Chen, Bowang;Hemminki, Kari
在一些癌症登记领域，过去几十年来，多发性骨髓瘤（MM）的发病率和死亡率呈上升趋势。对有多位受影响成员的家庭进行的系谱研究支持了由于共同的遗传因素而导致 MM 遗传性病因的假设。我们研究的目的有两个：1) 使用国家癌症登记数据评估 1961-2003 年间 MM 的发病趋势； 2) 使用瑞典家庭癌症数据库 2004 年更新来量化 MM 的家族风险。对于男性来说，1961-65 年的年龄标准化率为每 10 万人 4.33 人，2001-03 年为每 10 万人 4.79 人。女性的相应比率为 2.76 和 3.43。在老年人中，男性MM发病率从每10万人中28.7人上升到36.2人，女性从20.2人上升到24.5人。 MM 聚集在患有 MM（标准化发病率，SIR = 2.45）、非霍奇金淋巴瘤（SIR = 1.34）和慢性淋巴细胞白血病（SIR = 2.45）的家族中。没有发现与霍奇金淋巴瘤和其他白血病的关联。研究发现与直肠、胃、宫颈、前列腺、膀胱、内分泌腺和结缔组织恶性肿瘤有显着相关性。我们的研究进一步证明瑞典 MM 的发病率几十年来一直保持不变。在老年人中观察到的明显增加至少部分归因于诊断和认证的改进。多发性骨髓瘤在患有多发性骨髓瘤、慢性淋巴细胞白血病以及较小程度的非霍奇金淋巴瘤的家族中聚集。如果可以排除环境因素，MM的家族风险模式与常染色体显性遗传模式一致。 (c) 2006 Elsevier Ltd. 保留所有权利。
in several cancer registration areas, the trends in the incidence and mortality of multiple myeloma (MM) have been rising over the last few decades. Pedigrees studies on families with multiple affected members have supported the hypothesis of a contributing hereditary etiology of MM due to shared genetic factors. The aim of our study was twofold: 1) to assess incidence trends of MM over the period 1961-2003 using national cancer registry data and; 2) to quantify the familial risk of MM using the 2004 update of the Swedish Family-Cancer Database. For men, the age-standardized rates were 4.33 per 100 000 in 1961-65 and 4.79 in 2001-03. The corresponding rates for women were 2.76 and 3.43. In the elderly, MM rates have risen from 28.7 per 100 000 to 36.2 in men, and from 20.2 to 24.5 in women. MM clustered in families with MM (standardized incidence ratio, SIR = 2.45), non-Hodgkin lymphoma (SIR = 1.34) and chronic lymphocytic leukaemia (SIR = 2.45). No association was found for Hodgkin lymphoma and other leukaemias. Significant associations were found for rectal, stomach, cervical, prostate, bladder, endocrine glands and connective tissue malignancies. Our study adds further evidence that the incidence of MM in Sweden has been constant for several decades. The apparent increase observed in the elderly is, at least in part, attributable to improved diagnostics and certification. MM aggregates in families with MM, chronic lymphocytic leukaemia and, to a lesser extent, with non-Hodgkin lymphoma. if environmental factors can be excluded, the pattern of familial risk of MM is consistent with an autosomal dominant mode of inheritance. (c) 2006 Elsevier Ltd. All rights reserved.