The Target of Daptomycin Is Absent from Escherichia coli and Other Gram-Negative Pathogens
The Target of Daptomycin Is Absent from Escherichia coli and Other Gram-Negative Pathogens
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DOI：
10.1128/aac.02005-12
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发表时间：
2013-01-01
影响因子：
4.9
通讯作者：
O'Neill, Alex J.
中科院分区：
文献类型：
--
作者：
Randall, Christopher P.;Mariner, Katherine R.;O'Neill, Alex J.
由于外膜的通透性屏障和/或外排转运蛋白的作用，抗葡萄球菌药物通常对革兰氏阴性菌如大肠杆菌缺乏活性。当这些内在的耐药机制被人为地破坏时，这些药物几乎总是对革兰氏阴性菌表现出抗菌活性。在这里，我们展示了抗生素达托霉素的情况并非如此，它的靶标似乎在大肠杆菌和其他革兰氏阴性病原体中缺失。
Antistaphylococcal agents commonly lack activity against Gram-negative bacteria like Escherichia coli owing to the permeability barrier presented by the outer membrane and/or the action of efflux transporters. When these intrinsic resistance mechanisms are artificially compromised, such agents almost invariably demonstrate antibacterial activity against Gram negatives. Here we show that this is not the case for the antibiotic daptomycin, whose target appears to be absent from E. coli and other Gram-negative pathogens.