Evaluation the susceptibility of five polymorphisms in microRNA-binding sites to female breast cancer risk in Chinese population
Evaluation the susceptibility of five polymorphisms in microRNA-binding sites to female breast cancer risk in Chinese population
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DOI：
10.1016/j.gene.2015.07.052
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发表时间：
2015-11-15
期刊：
影响因子：
3.5
通讯作者：
Wang, Shu-Kui
中科院分区：
文献类型：
--
作者：
He, Bang-Shun;Pan, Yu-Qin;Wang, Shu-Kui
microRNA（miRNA）结合位点多态性与癌症风险的关系已被广泛讨论，但在中国人群中的相关性尚不清楚。为了研究miRNA结合位点的5个多态性（rs 11097457、rs 1434536、rs 1970801、rs 1044129、rs 11169571）与乳腺癌风险的关系，共435例女性乳腺癌患者和439例年龄和性别匹配的无肿瘤个体参加了这项病例对照研究。采用Sequenom MassARRAY法检测基因多态性，免疫组化法检测雌激素受体（ER）、孕激素受体（PR）和CerbB-2的表达。数据显示，这些多态性与所有参与者和亚组的乳腺癌风险或乳腺癌临床特征无关，但在14岁后首次月经的女性亚组中，携带rs 1970801 T等位基因（基因型TT/GT）的人与乳腺癌风险降低相关。简而言之，这项病例对照研究提供了证据，表明14岁以后首次月经并携带rs 1970801 T等位基因（基因型TT/GT）的女性与乳腺癌风险降低相关。(C)2015 Elsevier B. V.版权所有。
Polymorphisms in microRNA (miRNA) binding site have been widely discussed to be associated with cancer risk; however, the associations were unclear in Chinese population. To investigate the associations of five polymorphisms (rs11097457, rs1434536, rs1970801, rs1044129, rs11169571) in miRNA binding sites with breast cancer risk, a total of 435 female patients with breast cancer and 439 age- and gender-matched tumor-free individuals were enrolled in this case-control study. Sequenom MassARRAY was applied to detect the polymorphisms, and the immunohistochemistry assay was used to measure the expression of estrogen receptor (ER) and progesterone receptor (PR) and CerbB-2. The data showed that these polymorphisms were not associated with breast cancer risk or clinical characters of breast cancer in all participants and sub-group with the exception that, in the sub-group of women with their first menstruation after 14 years old, those who carried rs1970801 T allele (genotype TT/GT) were associated with decreased breast cancer risk. In short, this case-control study provided the evidence that women with their first menstruation after 14 years old and carried rs1970801 T allele (genotype TT/GT) were associated with decreased breast cancer risk. (C) 2015 Elsevier B.V. All rights reserved.