Restoration of Voluntary Muscle Strength After 3 Weeks of Cast Immobilization is Suppressed in Women Compared With Men
Restoration of Voluntary Muscle Strength After 3 Weeks of Cast Immobilization is Suppressed in Women Compared With Men
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DOI：
10.1016/j.apmr.2008.06.032
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发表时间：
2009-01-01
影响因子：
4.3
通讯作者：
Russ, David W.
中科院分区：
文献类型：
--
作者：
Clark, Brian C.;Manini, Todd M.;Russ, David W.
目的：研究固定后随意肌力损失和恢复的性别相关差异。设计：纵向重复测量。设置：研究实验室。参与者：健康男性（n=5）和健康女性（n=5）。干预：前臂固定三周。主要结果测量：在基线、固定期间每周和石膏取出后1周评估自愿腕关节屈曲肌力。中央激活进行了评估之前和之后的固定和I周的恢复，以确定什么百分比的肌肉可以被激活volunteer.Results：男性和女性失去了自愿的力量在固定在一个类似的速度。然而，在恢复一周后，男性的自主力量恢复到基线的1%以内，但女性仍比基线低约30%（P=0.03）。两种性别显示减少固定后的中央激活（P=0.02），但减少是相似的，在两种性别（P=0.82）。结论：这些研究结果表明，性别依赖的适应和恢复肢体制动，自愿力量恢复较慢的妇女。因此，针对性别的康复方案可能是必要的，女性在停用一段时间后需要额外或更密集的康复计划。今后需要开展工作，以确定这些差异的程度和机制。
Objective: To investigate sex-related differences in the loss and recovery of voluntary muscle strength after immobilization.Design: Longitudinal, repeated measures.Setting: Research laboratory.Participants: Healthy men (n=5) and healthy women (n=5).Intervention: Three weeks of forearm immobilization.Main Outcome Measures: Voluntary wrist flexion muscle strength was assessed at baseline and weekly during the immobilization protocol and 1 week after cast removal. Central activation was assessed before and after immobilization and after I week of recovery to determine what percentage of the muscle could be activated voluntarily.Results: Men and women lost voluntary strength at a similar rate during immobilization. However, after I week of recovery voluntary strength had returned to within 1% of baseline in the men, but remained approximately 30% less than baseline in the women (P=0.03). Both sexes displayed reduced central activation after immobilization (P=0.02), but the decrease was similar in both sexes (P=0.82).Conclusions: These findings suggest sex-dependent adaptations to and recovery from limb immobilization, with voluntary strength recovering slower in women. As such, sex-specific rehabilitation protocols may be warranted, with women requiring additional or more intensive rehabilitation programs after periods of disuse. Future work is needed to determine the extent and mechanisms of these differences.