How to make a curved Drosophila bristle using straight actin bundles
How to make a curved Drosophila bristle using straight actin bundles
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DOI：
10.1073/pnas.0509437102
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发表时间：
2005-12-27
影响因子：
11.1
通讯作者：
DeRosier, DJ
中科院分区：
文献类型：
--
作者：
Tilney, LG;DeRosier, DJ
这是我们作为科学院院士的首篇文章，颇具讽刺意味的是，它也是我们在肌动蛋白细胞骨架领域的绝唱。通过回顾我们所学到的知识以及我们认为在发育过程中所发生的情况，我们希望吸引读者您将您的技能应用于刚毛细胞。在一个便于进行基因操作的生物体中，肌动蛋白束的组装和拆卸过程在时间和空间上得以呈现。该细胞提供了你所能想到的每一个过程：丝状体成核、微绒毛生长、微绒毛束连接成模块、模块组装成束、至少两种交联蛋白的时间依赖性使用、丝状体周转、踏车运动、拆卸以及丝状体移位。
This, our Inaugural Article as Academy Members, is ironically our swan song from the field of the actin cytoskeleton. By reviewing what we have learned and what we think is going on during development, we hope to lure you, the reader, into applying your skills to the bristle cell. The processes of the assembly and disassembly of actin bundles is laid out in time and space in an organism that lends itself to genetic manipulation. The cell provides every process you could want: filament nucleation, growth of microvilli, joining of microvillar bundles into modules, assembly of modules into bundles, time-dependent use of at least two crossbridging proteins, filament turnover, treadmilling, disassembly, and filament translocation.