Social threat, fronto-cingulate-limbic morphometry, and symptom course in depressed adolescents: a longitudinal investigation.
Social threat, fronto-cingulate-limbic morphometry, and symptom course in depressed adolescents: a longitudinal investigation.
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DOI：
10.1017/s0033291722002239
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发表时间：
2023-08
影响因子：
6.9
通讯作者：
Ho TC
中科院分区：
文献类型：
--
作者：
Ojha A;Teresi GI;Slavich GM;Gotlib IH;Ho TC
以社会威胁为特征的心理社会应激源，如人际关系丧失和社会排斥，与青少年抑郁有关。然而，很少有研究研究社会威胁是否会影响与青少年抑郁症有关的额扣带回边缘系统。我们使用压力和逆境问卷评估了57名抑郁青少年(16.15±1.32岁，34名女性)在多个领域的终生应激源严重程度，并检查了社会威胁和非社会威胁应激源的严重程度是否与前扣带皮质(ACC)、杏仁核、海马体和伏隔核(NAcc)的灰质体积(GMV)有关。我们还研究了这些地区的终生社会威胁严重性和GMV与基线和9个月以上的抑郁症状之间的关系。一般应激源严重程度与基线及9个月以上的抑郁严重程度相关。此外，更严重的社会威胁(但不是非社会威胁)应激源与较小的双侧杏仁核和NAcc GMV，以及较小的尾侧和吻部前交叉韧带表面积相关(均为pFDR⩽0.048)。然而，无论是社会威胁还是非社会威胁应激源的严重程度都与海马区GMV无关(均为pFDR⩾0.318)。所有与社会威胁严重程度相关的额叶-扣带-边缘结构与9个月后更严重的抑郁严重程度呈负相关(均为pFDR⩽0.014)。专案后分析表明，双侧杏仁核、NAcc以及吻侧和尾侧ACC的灰质形态测量在9个月以上的青少年中调节了社会威胁与抑郁严重程度之间的关联(均为pFDR<；0.048)。社会威胁特别影响额叶-扣带-边缘通路，这些通路有助于青少年抑郁症的维持。
Psychosocial stressors characterized by social threat, such as interpersonal loss and social rejection, are associated with depression in adolescents. Few studies, however, have examined whether social threat affects fronto-cingulate-limbic systems implicated in adolescent depression. We assessed lifetime stressor severity across several domains using the Stress and Adversity Inventory (STRAIN) in 57 depressed adolescents (16.15 ± 1.32 years, 34 females), and examined whether the severity of social threat and non-social threat stressors was associated with gray matter volumes (GMVs) in the anterior cingulate cortex (ACC), amygdala, hippocampus, and nucleus accumbens (NAcc). We also examined how lifetime social threat severity and GMVs in these regions related to depressive symptoms at baseline and over 9 months. General stressor severity was related to greater depression severity at baseline and over 9 months. Moreover, greater severity of social threat (but not non-social threat) stressors was associated with smaller bilateral amygdala and NAcc GMVs, and smaller bilateral surface areas of caudal and rostral ACC (all pFDR ⩽ 0.048). However, neither social threat nor non-social threat stressor severity was related to hippocampal GMVs (all pFDR ⩾ 0.318). All fronto-cingulate-limbic structures that were associated with the severity of social threat were negatively associated with greater depression severity over 9 months (all pFDR ⩽ 0.014).Post-hoc analyses suggested that gray matter morphometry of bilateral amygdala, NAcc, and rostral and caudal ACC mediated the association between social threat and depression severity in adolescents over 9 months (all pFDR < 0.048). Social threat specifically affects fronto-cingulate-limbic pathways that contribute to the maintenance of depression in adolescents.