Reduced platelet vesicular monoamine transporter density in Tourette's syndrome pediatric male patients
Reduced platelet vesicular monoamine transporter density in Tourette's syndrome pediatric male patients
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DOI：
10.1016/j.euroneuro.2007.01.002
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发表时间：
2007-07-01
影响因子：
5.6
通讯作者：
Weizman, Abraham
中科院分区：
文献类型：
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作者：
Ben-Dor, David H.;Zimmerman, Sharon;Weizman, Abraham
囊泡单胺转运蛋白2（VMAT 2）在突触聚集和量子化中起主要作用。释放单胺。在这项研究中，我们评估了一组未经治疗的抽动秽语综合征（TS）患者（年龄：8-17.5岁，n=9）和一组年龄和性别匹配的健康对照组（年龄：9-16岁，n= 16）中[H-3]二氢丁苯那嗪与血小板VMAT 2的高亲和力结合。在TS患者中观察到血小板VMAT 2密度（B-max）显著降低（-23%，p = 0.016）。两组配体对血小板VMAT 2的亲和力（Kd）相似。如果较低的血小板VMAT 2密度也发生在大脑中，它可能是一种适应性机制，旨在减少突触前神经元中的多巴胺储存，从而减弱多巴胺能过度活动并改善运动障碍。(c)2007年Elsevier B. V.和ECNR AtI。rights reserved.
The vesicular monoamine transporter (VMAT2) plays a major rote in the synaptic accumulation and quantal. release of monoamines. In this study, we assessed high affinity [H-3] dihydrotetrabenazine binding to platelet VMAT2, in a group of untreated mate Tourette's syndrome (TS) patients (age: 8-17.5 years, n=9) and in a group of age- and sex-matched healthy controls (age: 9-16 years, n= 16). Significantly decreased platelet VMAT2 density (B-max) (-23%, p = 0.016) was observed in the TS patients. The affinity (Kd) of the ligand to platelet VMAT2 was similar in both groups. If the lower platelet VMAT2 density also occurred in the brain, it may have serve as an adaptive mechanism geared to decrease dopamine storage in the presynaptic neurons and thereby to attenuate the dopaminergic overactivity and ameliorate the movement disorder. (c) 2007 Elsevier B.V. and ECNR AtI. rights reserved.