Physical limits on cellular directional mechanosensing
Physical limits on cellular directional mechanosensing
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DOI：
10.1103/physreve.87.052716
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发表时间：
2013-05-29
影响因子：
2.4
通讯作者：
Yue, Dick K. P.
中科院分区：
文献类型：
--
作者：
Bouffanais, Roland;Sun, Jianmin;Yue, Dick K. P.
许多真核细胞能够通过直接测量其膜上的机械应力的微小空间差异来执行定向机械传感。在这里，我们探讨了一个单一的机械敏感通道激活的限制，使用两个状态的双井模型的门控机制。然后，我们专注于定向mechanosensing由一个单一的细胞具有多个mechanosensors的物理限制，并受到剪切流诱导不均匀的膜张力。我们的研究结果表明，在感测的机械刺激方向的准确性不仅随着细胞的大小和暴露的信号，但也增长的细胞与近临界膜预应力。最后，发现了非线性阈值效应的存在，从根本上限制了细胞在低信噪比下有效执行定向机械感知的能力。
Many eukaryotic cells are able to perform directional mechanosensing by directly measuring minute spatial differences in the mechanical stress on their membranes. Here, we explore the limits of a single mechanosensitive channel activation using a two-state double-well model for the gating mechanism. We then focus on the physical limits of directional mechanosensing by a single cell having multiple mechanosensors and subjected to a shear flow inducing a nonuniform membrane tension. Our results demonstrate that the accuracy in sensing the mechanostimulus direction not only increases with cell size and exposure to a signal, but also grows for cells with a near-critical membrane prestress. Finally, the existence of a nonlinear threshold effect, fundamentally limiting the cell's ability to effectively perform directional mechanosensing at a low signal-to-noise ratio, is uncovered.