Twist induces an epithelial-mesenchymal transition to facilitate tumor metastasis
Twist induces an epithelial-mesenchymal transition to facilitate tumor metastasis
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DOI：
10.4161/cbt.3.11.1302
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发表时间：
2004-11-01
影响因子：
3.6
通讯作者：
Tuveson, DA
中科院分区：
文献类型：
--
作者：
Karreth, F;Tuveson, DA
肿瘤转移--原发肿瘤细胞向远端器官扩散--是癌症患者死亡的主要原因。转移过程包括四个不同的步骤，即侵袭、内渗、外渗和转移生长，原代肿瘤细胞需要获得不同的遗传特征才能完成每一步。然而，转移过程中的主要参与者仍然很大程度上是未知的。Robert Weinberg的研究小组(Yang et al.，Cell 2004；117：927-39)最近在《细胞》杂志上发表的一篇报告将转录因子Twist添加到了转移调控因子的列表中。抑制Twist在肿瘤细胞中的表达可抑制其转移潜能，而其过表达则可诱导上皮细胞发生上皮-间充质转化(EMT)。这项研究提供了直接证据，表明EMT可能是转移过程中的一个重要过程，并应适当地促进许多实验室对EMT的进一步研究。
Tumor metastasis-the spreading of primary tumor cells to distal organs - is the major cause of death of cancer patients. The metastatic process consists of four distinct steps, invasion, intravasation, extravasation, and metastatic growth, and primary tumor cells need to acquire different genetic characteristics to accomplish each step. The main players during the metastatic process remain, however, largely unknown. A recent report in Cell by Robert Weinberg's group (Yang et al., Cell 2004;117:927-39) adds the transcription factor Twist to the list of metastatis regulators. Suppression of Twist expression in tumor cells inhibits the metastatic potential, whereas its overexpression induces an epithelial-mesenchymal transition (EMT) in epithelial cells. This study provides direct evidence that EMT may be an essential process during metastasis and should appropriately stimulate further investigations of EMT in many laboratories.