The role of microtubules in the regulation of epithelial junctions.
The role of microtubules in the regulation of epithelial junctions.
复制标题
DOI：
10.1080/21688370.2018.1539596
复制
发表时间：
2018
期刊：
影响因子：
3.1
通讯作者：
Citi S
中科院分区：
文献类型：
--
作者：
Vasileva E;Citi S
细胞骨架对于细胞与细胞连接的组装及其功能的稳态调节至关重要。反过来，连接蛋白充当细胞骨架丝的锚，以及细胞骨架动力学和信号蛋白的调节剂。连接和细胞骨架之间的串扰对于上皮组织和其他组织的形态发生和生理学至关重要，但尚未完全了解。微管参与将连接蛋白递送至细胞与细胞接触位点、细胞质的分化和空间组织以及连接的屏障和粘附功能的稳定。在这里，我们重点关注脊椎动物上皮细胞微管和连接之间的关系。我们重点介绍了微管-连接相互作用的分子基础的最新发现，并报告了有关扣带蛋白和副扣带蛋白与微管相互作用的新数据。我们还提出了连接可能作为微管相关信号蛋白的“分子汇”的新作用。
The cytoskeleton is crucially important for the assembly of cell-cell junctions and the homeostatic regulation of their functions. Junctional proteins act, in turn, as anchors for cytoskeletal filaments, and as regulators of cytoskeletal dynamics and signalling proteins. The cross-talk between junctions and the cytoskeleton is critical for the morphogenesis and physiology of epithelial and other tissues, but is not completely understood. Microtubules are implicated in the delivery of junctional proteins to cell-cell contact sites, in the differentiation and spatial organization of the cytoplasm, and in the stabilization of the barrier and adhesive functions of junctions. Here we focus on the relationships between microtubules and junctions of vertebrate epithelial cells. We highlight recent discoveries on the molecular underpinnings of microtubule-junction interactions, and report new data about the interaction of cingulin and paracingulin with microtubules. We also propose a possible new role of junctions as “molecular sinks” for microtubule-associated signalling proteins.