PERINATAL EXPOSURE TO POLYCHLORINATED-BIPHENYLS AND DIOXINS AND ITS EFFECT ON NEONATAL NEUROLOGICAL DEVELOPMENT
PERINATAL EXPOSURE TO POLYCHLORINATED-BIPHENYLS AND DIOXINS AND ITS EFFECT ON NEONATAL NEUROLOGICAL DEVELOPMENT
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DOI：
10.1016/0378-3782(94)01611-r
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发表时间：
1995-04-14
影响因子：
2.5
通讯作者：
BOERSMA, ER
中科院分区：
文献类型：
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作者：
HUISMAN, M;KOOPMANESSEBOOM, C;BOERSMA, ER
多氯联苯（PCBs）和二恶英（PCDDs和PCDFs）是广泛存在的环境污染物，对动物具有神经毒性。围产期接触多氯联苯、多氯二苯并对二恶英和多氯二苯并呋喃在产前通过胎盘发生，在产后通过母乳发生。为了研究这种暴露是否会影响新生儿的神经系统状况，418名荷兰新生儿的神经系统最优性进行了评估与Prechtl神经系统检查。一半婴儿是母乳喂养的，另一半是配方奶喂养的，分别代表出生后接触水平相对较高和较低的婴儿。作为产前暴露的指标，四个非平面的多氯联苯在脐带和母体血浆中使用。这些PCB水平与神经功能无关。作为新生儿出生前和新生儿早期接触的综合措施，在分娩后第二周的母乳中测定了17种二恶英同系物、3种平面多氯联苯同系物和23种非平面多氯联苯同系物。母乳中多氯联苯、多氯二苯并对二恶英和多氯二苯并呋喃含量较高与新生儿神经系统最佳状态降低有关。母乳中较高水平的平面多氯联苯与张力减退的发病率较高。这项研究证实了先前关于这些化合物对新生儿大脑发育的神经毒性作用的报道。
Polychlorinated biphenyls (PCBs) and dioxins (polychlorinated dibenzo-p-dioxins (PCDDs), and dibenzofurans (PCDFs)) are widespread environmental contaminants which are neurotoxic in animals. Perinatal exposure to PCBs, PCDDs, and PCDFs occurs prenatally via the placenta and postnatally via breast milk. To investigate whether such an exposure affects the neonatal neurological condition, the neurological optimality of 418 Dutch newborns was evaluated with the Prechtl neurological examination. Half of the infants were breast-fed, the other half were formula-fed, representing a relatively high against a relatively low postnatally exposed group, respectively. As an index of prenatal exposure, four non-planar PCBs in cord and maternal plasma were used. These PCB levels were not related to neurological function. As measures of combined pre- and early neonatal exposure, 17 dioxin congeners, three planar, and 23 non-planar PCB congeners were determined in human milk in the second week after delivery. Higher levels of PCBs, PCDDs, and PCDFs in breast milk were related to reduced neonatal neurological optimality. Higher levels of planar PCBs in breast milk were associated with a higher incidence of hypotonia. This study confirms previous reports about the neurotoxic effects of these compounds on the developing brain of newborn infants.