A systematic review of association studies investigating genes coding for serotonin receptors and the serotonin transporter: II. Suicidal behavior
A systematic review of association studies investigating genes coding for serotonin receptors and the serotonin transporter: II. Suicidal behavior
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DOI：
10.1038/sj.mp.4001336
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发表时间：
2003-01-01
影响因子：
11
通讯作者：
Turecki, G
中科院分区：
文献类型：
--
作者：
Anguelova, M;Benkelfat, C;Turecki, G
不同的5-羟色胺（5-HT）受体，包括5-羟色胺转运体（5-HTT），是自杀和自杀行为的优秀候选基因，因此，它们已经在大量的等位基因关联研究中进行了研究。这些研究的个别结果不一致，很难得出明确的结论。使用荟萃分析技术的系统评价提供了一种评估单个研究和生成综合结果的可靠方法。在这项研究中，我们对调查5-HT受体和5-HTT在自杀行为中的研究进行了系统回顾。通过MEDLINE数据库检索和扫描参考文献列表确定研究。共审查了190多篇文章，其中26篇符合纳入标准。共有14项研究调查了6个不同的5-HT受体位点，12项研究调查了5-HTT启动子44 bp插入/缺失多态性。进行了两项特定的荟萃分析，汇集了研究5-HT 2A 102 T/C和5-HTT启动子基因座的研究，分别包括总计1599和2539例受试者。联合证据表明与5-HTT基因座的关联显著（Mantel-Haenszel加权比值比（M-H-w OR）=1.17 CI：1.04-1.32，P=0.009），但与5-HT 2A 102 T/C变异的关联不显著（M-H-w OR =1.09 CI：0.93-1.27，P=0.319）。5-HTT的结果是稳健的，并在敏感性分析后保持显著性，表明5-HTT可能在自杀倾向中发挥作用。
The different serotonin (5-HT) receptors, including the serotonin transporter (5-HTT), are excellent candidate genes for suicide and suicidal behavior, and thus, they have been investigated in a large number of allelic association studies. The individual results of these studies have been inconsistent and definite conclusions are difficult to establish. A reliable method for assessing individual studies and generating combined results is provided by systematic reviews using meta-analytical techniques. In this study, we carried out a systematic review of studies investigating 5-HT receptors and the 5-HTT in suicidal behavior. Studies were identified by means of MEDLINE database searches and by scanning reference lists. More than 190 articles were reviewed and 26 met the inclusion criteria. In all, 14 studies investigated six different 5-HT receptor loci and 12 studies investigated the 5-HTT promoter 44bp insertion/deletion polymorphism. Two specific meta-analyses were carried out, pooling studies investigating the 5-HT2A 102 T/C and the 5-HTT promoter loci that included, respectively, a total of 1599 and 2539 subjects. The combined evidence was significant for association with the 5-HTT locus (Mantel-Haenszel weighted odds ratio (M-H-w OR)=1.17 CI:1.04-1.32, P=0.009), but not for the 5-HT2A 102 T/C variant (M-H-w OR)=1.09 CI: 0.93-1.27, P=0.319). The 5-HTT result was robust and remained significant following sensitivity analysis, suggesting that 5-HTT may play a role in the predisposition to suicide.