Parent-offspring inference in inbred populations.
Parent-offspring inference in inbred populations.
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DOI：
10.1111/1755-0998.13680
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发表时间：
2022-11
影响因子：
7.7
通讯作者：
Bendesky, Andres
中科院分区：
文献类型：
--
作者：
Runge, Jan-Niklas;Konig, Barbara;Lindholm, Anna K.;Bendesky, Andres
谱系关系是遗传研究的基本组成部分，即使在基因组范围内的信息中，构造也可以推断出正确和完整的谱系。他们的后代在自然，驯化和实验人群中常见，这些人群的基因分型通常比人类数据集更大，因此在这些条件下建立家谱的有效方法是必要的。父源关系，尤其是当饲养较高或存在基因分型误差时，或者两者都填充了谱系推理工具的武器库中的重要空隙。
Genealogical relationships are fundamental components of genetic studies. However, it is often challenging to infer correct and complete pedigrees even when genome‐wide information is available. For example, inbreeding can obscure genetic differences between individuals, making it difficult to even distinguish first‐degree relatives such as parent‐offspring from full siblings. Similarly, genotyping errors can interfere with the detection of genetic similarity between parents and their offspring. Inbreeding is common in natural, domesticated, and experimental populations and genotyping of these populations often has more errors than in human data sets, so efficient methods for building pedigrees under these conditions are necessary. Here, we present a new method for parent‐offspring inference in inbred pedigrees called specific parent‐offspring relationship estimation (spore). spore is vastly superior to existing pedigree‐inference methods at detecting parent‐offspring relationships, in particular when inbreeding is high or in the presence of genotyping errors, or both. spore therefore fills an important void in the arsenal of pedigree inference tools.
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影响因子：
4.5
作者：
Li H;Glusman G;Hu H;Shankaracharya;Caballero J;Hubley R;Witherspoon D;Guthery SL;Mauldin DE;Jorde LB;Hood L;Roach JC;Huff CD
通讯作者：
Huff CD
影响因子：
5.8
作者：
Li, Heng
通讯作者：
Li, Heng
影响因子：
10.7
作者：
Koch, Evan M.;Schweizer, Rena M.;Novembre, John
通讯作者：
Novembre, John
影响因子：
3.8
作者：
Alemu SW;Kadri NK;Harland C;Faux P;Charlier C;Caballero A;Druet T
通讯作者：
Druet T
影响因子：
3.3
作者：
Keller MC;Visscher PM;Goddard ME
通讯作者：
Goddard ME