HELICOBACTER-PYLORI GASTRITIS AND PRIMARY GASTRIC NON-HODGKINS-LYMPHOMAS
HELICOBACTER-PYLORI GASTRITIS AND PRIMARY GASTRIC NON-HODGKINS-LYMPHOMAS
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DOI：
10.1136/jcp.47.5.436
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发表时间：
1994-05-01
影响因子：
3.4
通讯作者：
FISCHER, R
中科院分区：
文献类型：
--
作者：
EIDT, S;STOLTE, M;FISCHER, R
目的：进一步探讨胃粘膜相关淋巴组织(MALT)恶性淋巴瘤与幽门螺杆菌(Hp)的关系。方法对162例胃MALT淋巴瘤手术标本进行回顾性分析，确定肿瘤类型和炎症类型。121例术前取活检标本，苏木精-伊红、高碘酸Schiff、Giemsa和Wartin-Starry染色。结果高度恶性MALT淋巴瘤残留淋巴滤泡的发生率低于低度恶性MALT淋巴瘤。146例标本中，143例在距肿瘤一定距离的粘膜内可见慢性活动性胃炎。在所有可以评估活检标本的病例中，都发生了幽门螺杆菌对粘膜的定植。82.7%的胃窦和85%的体黏膜标本中可检测到淋巴滤泡和淋巴集合体。结论：这些数据支持幽门螺杆菌在MALT淋巴瘤的发生发展中起重要作用的假说。此外，恶变前的慢性炎症可能通过对淋巴组织的慢性刺激增加恶变的可能性。这可能在一定程度上解释了为什么MALT淋巴瘤最常发生在胃里。
Aims-To evaluate further the relation between gastric malignant lymphoma of the mucosa associated lymphoid tissue (MALT) and Helicobacter pylori.Methods-One hundred and sixty two surgical specimens of MALT lymphoma were retrospectively investigated to determine tumour type, and inflammatory patterns. In 121 cases biopsy specimens obtained before surgery were available and stained with haematoxylin and eosin, periodic acid Schiff, Giemsa and Warthin-Starry stains.Results-Residual lymphoid follicles were found less often in high grade malignant than in low grade malignant MALT lymphomas. Chronic active gastritis was shown within the mucosa at some distance from the tumours in 143 of 146 specimens. In all the cases for which biopsy specimens could be evaluated, colonisation of the mucosa by H pylori had occurred. Lymphoid follicles and lymphoid aggregates were detected in 82.7% of the antral, and in 85% of the body mucosa specimens.Conclusions-These data support the hypothesis that H pylori has an important role in the development of MALT lymphomas. Furthermore, the chronic inflammation preceding malignant transformation might enhance the probability of malignant transformation via chronic stimulation of the lymphoid tissue. This might in part indicate why MALT lymphomas occur most often in the stomach.