KCl-CaCO3 nanoclusters armoured with Pt Nanocrystals for Enhanced Electro-driven Tumor Inhibition
KCl-CaCO3 nanoclusters armoured with Pt Nanocrystals for Enhanced Electro-driven Tumor Inhibition
复制标题
带有 Pt 纳米晶体的 KCl-CaCO3 纳米团簇可增强电驱动肿瘤抑制作用
DOI：
10.1039/d1bm01464a
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发表时间：
2022
影响因子：
6.6
通讯作者：
Xiang Li
中科院分区：
文献类型：
--
作者：
Tong Chen;Yike Fu;Ruoyu Zhang;Gaorong Han;Xiang Li
Electrodynamic therapy (EDT) has recently emerged as an alternative approach for tumor therapy via the generation of ROS by platinum (Pt) nanoparticles under electric field. An interesting phenomenon observed during EDT is that the increased on-site concentration of chloride ions is highly beneficial for ROS generation and inhibition efficacy. Here, in this study, nanoclusters (KCC), consisting of potassium chloride (KCl) nanocrystals and amorphous calcium carbonate (CaCO3), were synthesized and integrated with platinum nanoparticles (KCCP). In this system, KCC can dissolve and release calcium and chloride ions within tumor cells. The intracellular chloride ions considerably facilitated ROS generation by Pt nanoparticles under an electric field. More importantly, the excessive calcium ions and ROS formed a cycle of mutual promotion and self-amplification in cells, leading to agitated tumor inhibition, both in vitro and in vivo.
