Probiotic immunomodulation in health and disease
Probiotic immunomodulation in health and disease
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DOI：
10.1093/jn/130.2.403s
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发表时间：
2000-02-01
影响因子：
4.2
通讯作者：
Hubbard, NE
中科院分区：
文献类型：
--
作者：
Erickson, KL;Hubbard, NE
益生菌是通过影响肠道植物群而对宿主的生理和病理过程产生有利影响的微生物，可在改善人类健康方面发挥作用。其中一个假定的作用是调节免疫功能。因此，粘膜免疫系统和方法来评估其功能进行了简要的审查。本文综述了益生菌对体液免疫、细胞免疫和非特异性免疫的调节作用，重点介绍了益生菌在疾病模型中的免疫应答作用。益生菌对人体的干预研究报道很少，但对益生菌、免疫和人类健康的未来研究方向进行了讨论。虽然益生菌的应用已经证明了免疫反应方面的变化趋势，但其发生的潜在机制尚不清楚。
Probiotics, microorganisms that have a favorable influence on physiologic and pathological processes of the host by their effect on the intestinal flora, may play a role in improving human health. One of the putative effects is the modulation of immune function. Thus, the mucosal immune system and methods to assess its function are reviewed briefly. Probiotic modulation of humoral, cellular and nonspecific immunity is reviewed, with emphasis placed on immune response in disease models, There are very few reports of human intervention studies with probiotics, However, some of the possible future directions for research with respect to probiotics, immunity, and human health are discussed. Although the application of probiotics has demonstrated trends with respect to altered aspects of immune response, the underlying mechanisms by which that occurs are unclear.