Magnetic Nanoparticles for Therapy and Diagnostics
Magnetic Nanoparticles for Therapy and Diagnostics
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DOI：
10.1109/tmag.2012.2220757
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发表时间：
2013
影响因子：
2.1
通讯作者：
E. Pollert;P. Kašpar;K. Závěta;V. Herynek;M. Burian;P. Jendelová
中科院分区：
文献类型：
--
作者：
E. Pollert;P. Kašpar;K. Závěta;V. Herynek;M. Burian;P. Jendelová
磁性纳米粒子的研究和应用，磁铁矿Fe_3O_4和磁赤铁矿γ-Fe_2O_3已成为生物医药的首选材料。复合氧化物允许以期望的方式更好地控制磁性。我们证明了这种方法的一个例子的La 1-xSrxMnO 3钙钛矿的角度来看，它们的使用在自我控制的磁流体热疗和磁共振成像中的对比度的增加。随着材料具有合适的值的转变温度TC，介电常数和磁化强度，由纳米粒子产生的加热功率估计由两个独立的方法，他们最终在体外和体内热疗实验。
The research and utilization of the magnetic nanoparticles in, e.g., biology and medicine have been preferentially oriented on magnetite Fe3O4 and maghemite γ-Fe2O3. The complex oxides allow a better control of the magnetic properties in a desirable way. We demonstrate this approach on an example of the La1-xSrxMnO3 perovskites from the point of view of their use in self-controlled magnetic fluid hyperthermia and increase of contrast in magnetic resonance imaging. With materials possessing suitable values of transition temperature TC, coercivity and magnetization, the heating power generated by the nanoparticles was estimated by two independent methods and they were finally employed in vitro and in vivo hyperthermia experiments.