Establishment of a new animal model of metabolic syndrome:: SHRSP fatty (fa/fa) rats
Establishment of a new animal model of metabolic syndrome:: SHRSP fatty (fa/fa) rats
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DOI：
10.1111/j.1440-1681.2004.03962.x
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发表时间：
2004-01-01
影响因子：
2.9
通讯作者：
Ikeda, K
中科院分区：
文献类型：
--
作者：
Hiraoka-Yamamoto, J;Nara, Y;Ikeda, K
1.通过将易卒中型自发性高血压大鼠（SHRSP/Izm）与Zucker fatty（fa/fa）大鼠杂交，建立了一种新的代谢综合征动物模型SHRSP fatty（fa/fa）大鼠. SHRSP肥胖（fa/fa）大鼠具有瘦素受体基因的错义突变，并且血浆瘦素浓度增加。SHRSP肥胖（fa/fa）大鼠易发生肥胖和高血压.与SHRSP/Izm大鼠相比，SHRSP脂肪（fa/fa）大鼠的血浆代谢参数，包括葡萄糖、胰岛素、总胆固醇和甘油三酯水平显著升高。与ZF（fa/fa）大鼠相比，SHRSP肥胖（fa/fa）大鼠血浆甘油三酯浓度显著升高。SHRSP脂肪组（fa/fa）大鼠的脂肪组织重量大于SHRSP/Izm组。SHRSP肥胖（fa/fa）大鼠的表型与人类代谢综合征的表型相似。
1. We established a new animal model of metabolic syndrome, SHRSP fatty (fa/fa) rats, by crossing stroke-prone spontaneously hypertensive rats of the Izumo strain (SHRSP/Izm) to Zucker fatty (ZF) (fa/fa) rats.2. The SHRSP fatty (fa/fa) rats have a missense mutation of the leptin receptor gene and plasma leptin concentrations are augmented. The SHRSP fatty (fa/fa) rats develop obesity and hypertension simultaneously.3. Plasma metabolic parameters, including glucose, insulin and total cholesterol and triglyceride levels, were markedly elevated in SHRSP fatty (fa/fa) rats compared with SHRSP/Izm rats. Plasma triglyceride concentrations in SHRSP fatty (fa/fa) rats were significantly elevated compared with those in ZF (fa/fa) rats. The weight of adipose tissues in SHRSP fatty (fa/fa) rats was greater than that of SHRSP/Izm rats. The phenotype of SHRSP fatty (fa/fa) rats is similar to that of human metabolic syndrome.