In vivo effects of coronavirus-specific T cell clones: DTH inducer cells prevent a lethal infection but do not inhibit virus replication.
In vivo effects of coronavirus-specific T cell clones: DTH inducer cells prevent a lethal infection but do not inhibit virus replication.
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冠状病毒特异性 T 细胞克隆的体内作用：DTH 诱导细胞可预防致命感染，但不会抑制病毒复制。
DOI：
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发表时间：
1986
影响因子：
4.4
通讯作者：
Leslie P. Weiner
中科院分区：
文献类型：
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作者：
S. Stohlman;Glenn K. Matsushima;N. Casteel;Leslie P. Weiner
通过局部过继转移3个病毒特异性Lyt-1+2-、L3T4+T细胞克隆，防止了嗜神经性小鼠肝炎病毒JHM株的致死性感染。转移Lyt-1+T细胞对无关抗原(鸡蛋溶菌酶)没有保护作用。保护需要T细胞和受体之间的I区相容，通过在移植前照射细胞或用环磷酰胺预处理受体而被逆转。过继转移阻止了由于JHM病毒感染而导致的死亡，但并未导致抗病毒免疫球蛋白合成的改变或中枢神经系统(CNS)中病毒复制的抑制。这些数据表明，在保护宿主免受嗜神经性病毒致死性感染的CNS中，局部DTH反应是必要的，但清楚地表明，其他抗病毒效应机制对于抑制病毒复制是必要的。
A lethal infection by neurotropic JHM strain of mouse hepatitis virus was prevented by the local adoptive transfer of three virus-specific Lyt-1+2-, L3T4+ T cell clones. The transfer of Lyt-1+ T cells specific for an unrelated antigen (hen egg lysozyme) did not protect. Protection required I region compatibility between the T cells and the recipients, and was reversed either by irradiation of the cells before transfer or by pretreatment of the recipients with cyclophosphamide. Adoptive transfer prevented death due to JHM virus infection but did not result in altered antiviral immunoglobulin synthesis or the suppression of viral replication in the central nervous system (CNS). The data presented implicate a local DTH response in the protection of the host from lethal infection of the CNS by a neurotropic virus, but clearly imply that other antiviral effector mechanisms are necessary for the suppression of viral replication.