Human infections with Shiga toxin-producing Escherichia coli other than serogroup O157 in Germany.
Human infections with Shiga toxin-producing Escherichia coli other than serogroup O157 in Germany.
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DOI：
10.3201/eid0404.980415
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发表时间：
1998-10
影响因子：
11.8
通讯作者：
Gleier, K
中科院分区：
文献类型：
--
作者：
Beutin, L;Zimmermann, S;Gleier, K
我们调查了不同类型的不属于O157血清组的志贺毒素产毒大肠杆菌(STEC)作为人类病原体的作用。从德国89名人类患者中分离的非O157 STEC根据血清型、毒力标记和与人类疾病的相关性进行了特征分析。从54例(60.7%)患者中分离出EaeA阳性的STEC，并经常与严重腹泻疾病、溶血性尿毒症综合征和年轻有关。EaeA阴性STEC 35例(39.3%)，多见于临床无并发症患者和成人患者。对于儿科患者，建议对STEC进行非血清型诊断。
We investigated different types of Shiga toxin-producing Escherichia coli (STEC) not belonging to serogroup O157 for their role as human pathogens. Non-O157 STEC isolated from 89 human patients in Germany were characterized according to serotypes, virulence markers, and association with human illness. EaeA-positive STEC were isolated from 54 (60.7%) of the patients and were frequently associated with severe diarrheal disease, hemolytic uremic syndrome, and young age. EaeA-negative STEC were found in 35 (39.3%) of the patients and were more associated with clinically uncomplicated cases and adult patients. For pediatric patients, a serotype-independent diagnosis of STEC is recommended.