The interplay of extracellular matrix and microbiome in urothelial bladder cancer.
The interplay of extracellular matrix and microbiome in urothelial bladder cancer.
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DOI：
10.1038/nrurol.2015.292
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发表时间：
2016-02
期刊：
影响因子：
--
通讯作者：
Salonia A
中科院分区：
文献类型：
--
作者：
Alfano M;Canducci F;Nebuloni M;Clementi M;Montorsi F;Salonia A
The interplay between tumour cells and the extracellular microenvironment has been recognized as one of the key determinants of cancer development and progression Interaction between extracellular matrix components and bacterial products controls tissue homeostasis; its dysregulation might prepare protumorigenic environmental niches, which could also favour disease relapse Bladder colonization with specific bacterial genera throughout an individual's lifetime might influence the propensity for bladder pathology and partly explain the gender differences in the rate of urinary diseases Extracellular-matrix-based and microbiota-based biomarkers might be new prognostic factors in bladder cancer, exploitable for risk stratification, tumour staging and for predicting relapse and outcome Targeting the bladder extracellular matrix or the associated microbiota might bypass treatment resistance mechanisms of tumour cells The online version of this article (doi:10.1038/nrurol.2015.292) contains supplementary material, which is available to authorized users. The interaction between tumour cells and their microenvironment has an important role in cancer pathogenesis. Alfano et al. review how dysregulation of the extracellular matrix and microbiota associated with the human epithelium might influence the development and progression of urothelial carcinomas. The online version of this article (doi:10.1038/nrurol.2015.292) contains supplementary material, which is available to authorized users. Many pathological changes in solid tumours are caused by the accumulation of genetic mutations and epigenetic molecular alterations. In addition, tumour progression is profoundly influenced by the environment surrounding the transformed cells. The interplay between tumour cells and their microenvironment has been recognized as one of the key determinants of cancer development and is being extensively investigated. Data suggest that both the extracellular matrix and the microbiota represent microenvironments that contribute to the onset and progression of tumours. Through the introduction of omics technologies and pyrosequencing analyses, a detailed investigation of these two microenvironments is now possible. In urological research, assessment of their dysregulation has become increasingly important to provide diagnostic, prognostic and predictive biomarkers for urothelial bladder cancer. Understanding the roles of the extracellular matrix and microbiota, two key components of the urothelial mucosa, in the sequelae of pathogenic events that occur in the development and progression of urothelial carcinomas will be important to overcome the shortcomings in current bladder cancer treatment strategies. The online version of this article (doi:10.1038/nrurol.2015.292) contains supplementary material, which is available to authorized users.
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影响因子：
64.8
作者：
Arumugam, Manimozhiyan;Raes, Jeroen;Pelletier, Eric;Le Paslier, Denis;Yamada, Takuji;Mende, Daniel R.;Fernandes, Gabriel R.;Tap, Julien;Bruls, Thomas;Batto, Jean-Michel;Bertalan, Marcelo;Borruel, Natalia;Casellas, Francesc;Fernandez, Leyden;Gautier, Laurent;Hansen, Torben;Hattori, Masahira;Hayashi, Tetsuya;Kleerebezem, Michiel;Kurokawa, Ken;Leclerc, Marion;Levenez, Florence;Manichanh, Chaysavanh;Nielsen, H. Bjorn;Nielsen, Trine;Pons, Nicolas;Poulain, Julie;Qin, Junjie;Sicheritz-Ponten, Thomas;Tims, Sebastian;Torrents, David;Ugarte, Edgardo;Zoetendal, Erwin G.;Wang, Jun;Guarner, Francisco;Pedersen, Oluf;de Vos, Willem M.;Brunak, Soren;Dore, Joel;Weissenbach, Jean;Ehrlich, S. Dusko;Bork, Peer
通讯作者：
Bork, Peer
影响因子：
7.5
作者：
Brandau, Sven;Suttmann, Henrik
通讯作者：
Suttmann, Henrik
影响因子：
--
作者：
Aprile, Giuseppe;Avellini, Claudio;Piga, Andrea
通讯作者：
Piga, Andrea
影响因子：
3.1
作者：
AZGHANI, AO;GRAY, LD;JOHNSON, AR
通讯作者：
JOHNSON, AR
影响因子：
6
作者：
Aitken, Karen J.;Block, Gregory;Bagli, Darius J.
通讯作者：
Bagli, Darius J.