EFFECT OF 1,25-DIHYDROXYCHOLECALCIFEROL ON SARCOPLASMIC-RETICULUM CALCIUM-TRANSPORT IN STRONTIUM-FED CHICKS
EFFECT OF 1,25-DIHYDROXYCHOLECALCIFEROL ON SARCOPLASMIC-RETICULUM CALCIUM-TRANSPORT IN STRONTIUM-FED CHICKS
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DOI：
10.1007/bf02405030
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发表时间：
1983-01-01
影响因子：
4.2
通讯作者：
HASSELBACH, W
中科院分区：
文献类型：
--
作者：
BOLAND, R;DEBOLAND, AR;HASSELBACH, W
用肾脏合成1，25-二羟基胆钙化醇的抑制剂Sr饲喂雏鸡7天，可显著抑制骨骼肌肌浆网膜钙摄取的起始速率和钙贮存能力。口服给药1，25（OH）2D 3锶喂养的动物返回钙转运值正常。所观察到的变化可能与运输ATP酶和钙结合蛋白的相对比例的差异无关。结果与1，25（OH）2D 3在肌肉功能中的作用一致。
Feeding of chicks with Sr, an inhibitor of 1,25-dihydroxycholecalciferol synthesis in kidney, during 7 days, significantly depressed the initial rate of Ca uptake and Ca storing capacity of sarcoplasmic reticulum membranes from skeletal muscle. Oral administration of 1,25(OH)2D3 to Sr-fed animals returned Ca transport values to normal. The changes observed could not be related to differences in the relative proportions of transport ATPase and Ca binding proteins. The results are consistent with a role of 1,25(OH)2D3 in muscle function.