Group A streptococcal immunoglobulin-binding proteins: adhesins, molecular mimicry or sensory proteins?
Group A streptococcal immunoglobulin-binding proteins: adhesins, molecular mimicry or sensory proteins?
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A 组链球菌免疫球蛋白结合蛋白：粘附素、分子模拟或感觉蛋白？
DOI：
10.1016/0966-842x(94)90600-9
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发表时间：
1994
影响因子：
15.9
通讯作者：
Retnoningrum,D
中科院分区：
文献类型：
--
作者：
Cleary,P;Retnoningrum,D
致病性链球菌在其表面表达多种免疫球蛋白结合蛋白(IGPs)，这些蛋白在序列和结构上与抗噬细胞M蛋白相似。两者都是一个复制的祖先基因的进化产物，都是病毒基因簇的组成部分。除了M蛋白以外，几乎没有直接的实验证据表明IGPs参与了发病机制。对IGP的几种功能进行了假设和讨论。
Pathogenic streptococci express multiple immunoglobulin-binding proteins (IGPs) on their surface that are similar in sequence and structure to the antiphagocytic M proteins. Both are evolutionary products of a duplicated ancestral gene and are components of theVirgene cluster. Except for M proteins, there is little direct experimental evidence to implicate IGPs in pathogenesis. Several functions of IGPs are postulated and discussed.