SPONTANEOUS CANINE KERATOCONJUNCTIVITIS SICCA - A USEFUL MODEL FOR HUMAN KERATOCONJUNCTIVITIS SICCA - TREATMENT WITH CYCLOSPORINE EYE DROPS
SPONTANEOUS CANINE KERATOCONJUNCTIVITIS SICCA - A USEFUL MODEL FOR HUMAN KERATOCONJUNCTIVITIS SICCA - TREATMENT WITH CYCLOSPORINE EYE DROPS
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DOI：
10.1001/archopht.1989.01070020276038
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发表时间：
1989-08-01
影响因子：
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通讯作者：
WARD, DA
中科院分区：
文献类型：
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作者：
KASWAN, RL;SALISBURY, MA;WARD, DA
对36例连续的犬干燥性角结膜炎（KCS）病例使用眼科用环孢素进行了治疗。局部应用环孢素的作用有两方面：（1）在所有初始希尔默泪液试验值大于2毫米/分钟的自发性KCS病例以及初始希尔默泪液试验值为0 - 2毫米/分钟的59%的眼中，环孢素使泪液产生量增加了5毫米/分钟或更多；（2）即使在泪液分泌未能改善的眼中，环孢素也能使慢性角膜新生血管和肉芽组织显著消退。局部应用环孢素的其他益处包括减少黏脓性结膜炎、使不愈合的角膜溃疡快速愈合以及减少对KCS频繁局部治疗的依赖。与基线或安慰剂对照治疗的犬相比，12只局部应用环孢素治疗的正常比格犬的泪液分泌也有可逆性增加。
Thirty-six sequential cases of canine keratoconjunctivitis sicca (KCS) were treated with ophthalmic cyclosporine. The effects of topical cyclosporine were twofold: (1) cyclosporine increased tear production by 5 mm/min or greater in all cases of spontaneous KCS having an initial Schirmer''s Tear Test value greater than 2 mm/min and in 59% of eyes with an initial Schirmer''s Tear Test value of 0 to 2 mm/min, and (2) cyclosporine caused marked regression of chronic corneal neovascularization and granulation even in eyes in which lacrimation failed to improve. Additional benefits of topical cyclosporine were reduced mucopurulent conjunctivitis, rapid healing of nonhealing corneal ulcers, and reduced dependence on frequent topical treatments of KCS. Twelve normal beagles treated with topical cyclosporine also had a reversible increase in lacrimation compared with baseline or placebo control-treated dogs.