H-coil: Induced electric field properties and input/output curves on healthy volunteers, comparison with a standard figure-of-eight coil
H-coil: Induced electric field properties and input/output curves on healthy volunteers, comparison with a standard figure-of-eight coil
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DOI：
10.1016/j.clinph.2009.02.176
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发表时间：
2009-06-01
影响因子：
4.7
通讯作者：
Nitsche, Michael A.
中科院分区：
文献类型：
--
作者：
Fadini, Tommaso;Matthaeus, Lars;Nitsche, Michael A.
目的：为了获得有关H-coil.Methods的物理特性和生理效应的信息：我们使用了一个自动化系统来测量由H-coil原型产生的电场（E-场），并将其与标准的8字形线圈进行比较。为了探索线圈的生理特性，记录了右小指展肌（ADM）作为靶肌肉的输入/输出曲线。为了探索刺激的焦点，同时记录左ADM，右拇短展肌（APB），伸趾总肌（EDC）和肱二头肌（BB）muscles.Results：物理测量的H线圈显示了4个潜在的刺激焦点，产生不同的电持有强度沿着两个不同的空间方向。与8字形线圈刺激相比，H线圈的RMT显著较低。当输入-输出曲线的刺激强度由最大刺激器输出的百分比确定时，与8字形线圈相比，由于H线圈的刺激强度的较大相对增强，H线圈在右侧ADM中产生较大的MEP。当刺激强度调整为RMT时，8字形线圈在右ADM处引起的MEP大于H线圈刺激，而这种关系在远距离非靶肌肉中逆转，具有低刺激强度。在高刺激强度下，H线圈引起所有测试肌肉的较大MEP。发病潜伏期的MEN是从来没有短于H-线圈比数字的8线圈刺激的目标muscles.Conclusions：这些结果是有利于一个非焦点，但不是更深的影响的H-线圈，相比，一个数字的8 coil.Significance：这是第一个神经生理学研究探索的焦点和深度的刺激提供的H-线圈系统在人类。我们发现，与8字形线圈相比，该线圈在刺激深度方面没有优势。未来的研究必须表明该线圈的非聚焦性是否与其他非聚焦线圈（例如圆形线圈）的非聚焦性有相关差异。(C)2009年国际临床神经生理学联合会。由Elsevier爱尔兰有限公司出版。保留所有权利。
Objective: To acquire information about the physical properties and physiological effects of the H-coil.Methods: We used a robotized system to measure the electric field (E-field) generated by a H-coil prototype and compared it with a standard figure-of-eight coil. To explore the physiological properties of the coils, input/output curves were recorded for the right abductor digiti minimi muscle (ADM) as target muscle. To explore focality of stimulation, simultaneous recordings were performed for the left ADM, right abductor pollicis brevis (APB), extensor digitorum communis (EDC) and biceps brachii (BB) muscles.Results: Physical measurements of the H-coil showed four potentially stimulating foci, generating different electric held intensities along two different spatial orientations. RMT was significantly lower for H-coil- as compared to figure-of-eight coil stimulation. When stimulation intensity for the input-output curve was determined by percent of maximum stimulator output, the H-coil produced larger MEPs in the right ADM, as compared to the figure-of-eight coil, due to the larger relative enhancement of stimulation intensity of the H-coil. When stimulation intensity was adjusted to RMT, MEPs elicited at the right ADM were larger for figure-of-eight coil than for H-coil stimulation, while this relation was reversed for distant non-target muscles, with low stimulation intensities. With high stimulation intensities, the H-coil elicited larger MEPs for all tested muscles. Onset latency of the MEN was never shorter for H-coil than for figure-of-eight coil stimulation of the target muscles.Conclusions: These results are in favor for a non-focal, but not deeper effect of the H-coil, as compared to a figure-of-eight coil.Significance: This is the first neurophysiological study exploring the focality and depth of stimulation delivered by the H-coil systematically in humans. We found no advantage of this coil with regard to depth Of Stimulation in comparison to the figure-of-eight coil. Future studies have to show if the non-focality of this coil differs relevantly from that of other non-focal coils, e.g. the round coil. (C) 2009 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.