Small intestinal microbiota: the neglected stepchild needed for fat digestion and absorption
Small intestinal microbiota: the neglected stepchild needed for fat digestion and absorption
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DOI：
10.1080/19490976.2018.1502539
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发表时间：
2019-01-01
期刊：
影响因子：
12.2
通讯作者：
Martinez-Guryn, Kristina
中科院分区：
文献类型：
--
作者：
Chang, Eugene B.;Martinez-Guryn, Kristina
我们最近在《细胞宿主与微生物》杂志上发表的论文“小肠微生物群调节对饮食脂质的消化和吸收适应性反应”探索了被忽视的小肠微生物群，并证明了其作为脂肪消化和吸收调节剂的关键作用。这项工作产生了以下重要的重要信息：1）小肠微生物对高脂肪饮食特别敏感，并开启调节脂肪消化和运输的宿主过程，2）这种作用很可能是由微生物群精心策划的，每种微生物都有不同的特定作用和目标，3）这个群的作用似乎是由细菌衍生的小分子或生物活性成分介导的。这些发现有望为开发营养不良或营养过剩的治疗方法提供见解。本附录的目的是总结我们的发现，解决与肠道微生物群和生殖研究相关的问题，特别是在技术和实验设计方面，在相关文献的背景下讨论这项工作，最后为未来的研究提供考虑。
Our recently published paper "Small Intestine Microbiota Regulate Digestive and Absorptive Adaptive Responses to Dietary Lipids" in Cell Host & Microbe explored the neglected small intestine microbiota and demonstrated its critical role as a regulator of fat digestion and absorption. This work generated the following important take home messages: 1) small intestinal microbes are particularly sensitive to high fat diets and turn on host processes regulating fat digestion and transport, 2) this action is very likely orchestrated by a consortium of microbes, each having different specific effects and targets, and 3) the actions of this consortium appear to be mediated by bacteria-derived small molecules or bioactive components. These findings are expected to provide insight into developing treatments for conditions of under- or over-nutrition. The goal of this addendum is to summarize our findings, address issues related to gut microbiota and gnotobiotic research specifically regarding technology and experimental design, discuss this work in the context of relevant literature, and lastly provide considerations for future research.