Global brain inflammation in stroke
Global brain inflammation in stroke
复制标题
中风引起的全身脑部炎症
DOI：
10.1016/s1474-4422(19)30078-x
复制
发表时间：
2019-11-01
期刊：
影响因子：
48
通讯作者：
Shi, Fu-Doug
中科院分区：
文献类型：
--
作者：
Shi, Kaibin;Tian, De-Cai;Shi, Fu-Doug
中风，包括急性缺血性中风和脑内出血，导致神经元细胞死亡和释放的因素，如损伤相关的分子模式（DAMP），引起局部炎症在受伤的大脑区域。这种局灶性脑炎症通过加重血脑屏障损伤、微血管衰竭、脑水肿、氧化应激和通过直接诱导神经元细胞死亡来加重继发性脑损伤。除了炎症局限于受伤的大脑区域，越来越多的证据表明，中风后的炎症反应发生并持续整个大脑。全脑炎症可能会持续塑造中风后的病理学演变，并影响患者的长期神经功能结局。未来的努力，以了解出现所谓的全球性脑炎症的机制，将有助于调节这种炎症作为一个潜在的治疗策略中风。
Stroke, including acute ischaemic stroke and intracerebral haemorrhage, results in neuronal cell death and the release of factors such as damage-associated molecular patterns (DAMPs) that elicit localised inflammation in the injured brain region. Such focal brain inflammation aggravates secondary brain injury by exacerbating blood-brain barrier damage, microvascular failure, brain oedema, oxidative stress, and by directly inducing neuronal cell death. In addition to inflammation localised to the injured brain region, a growing body of evidence suggests that inflammatory responses after a stroke occur and persist throughout the entire brain. Global brain inflammation might continuously shape the evolving pathology after a stroke and affect the patients' long-term neurological outcome. Future efforts towards understanding the mechanisms governing the emergence of so-called global brain inflammation would facilitate modulation of this inflammation as a potential therapeutic strategy for stroke.