Decreased conflict- and error-related activity in the anterior cingulate cortex in subjects with schizophrenia
Decreased conflict- and error-related activity in the anterior cingulate cortex in subjects with schizophrenia
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DOI：
10.1176/appi.ajp.162.10.1833
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发表时间：
2005-10-01
影响因子：
17.7
通讯作者：
Carter, CS
中科院分区：
文献类型：
--
作者：
Kerns, JG;Cohen, JD;Carter, CS
目的：精神分裂症患者在执行许多类型的认知任务和犯错误时，前扣带皮层的功能活动减少。根据冲突理论，前扣带皮层参与监控反应冲突，作为需要更大认知控制的信号。这项研究考察了精神分裂症患者冲突监控功能受损是否可能是在正确任务执行和错误相关活动中前扣带活动减少的基础。方法：采用事件相关功能磁共振成像和Stroop任务对13名精神分裂症患者和13名健康对照者的前扣带功能活动进行了研究。Stroop任务允许同时检查冲突（不一致试验）和错误（错误委员会试验）期间的活动。结果：在对冲突和错误率的可比反应时间测量中，精神分裂症受试者在前扣带皮层的同一区域显示出冲突和错误相关活动的减少。此外，精神分裂症患者并没有表现出明显的冲突后或错误后的行为调整。结论：前扣带皮层冲突和错误相关的活动同时减少，以及试验对试验的表现调整减少，这在精神分裂症中以前没有报道过。目前的结果表明，前扣带皮层的冲突监测受损可能在精神分裂症患者的认知控制缺陷中起重要作用。
Objective: People with schizophrenia have exhibited reduced functional activity in the anterior cingulate cortex during the performance of many types of cognitive tasks and during the commission of errors. According to conflict theory, the anterior cingulate cortex is involved in the monitoring of response conflict, acting as a signal for a need for greater cognitive control. This study examined whether impaired conflict monitoring in people with schizophrenia could underlie reduced anterior cingulate activity during both correct task performance and error-related activity.Method: Functional activity in the anterior cingulate of 13 schizophrenia patients and 13 healthy comparison subjects was investigated by using event-related fMRI and a Stroop task that allowed simultaneous examination of activity during both conflict (incongruent trials) and error (commission of error trials).Results: In the presence of comparable reaction time measures for conflict as well as comparable error rates, the schizophrenia subjects showed both decreased conflict- and error-related activity in the same region of the anterior cingulate cortex. Moreover, those with schizophrenia did not exhibit significant post-conflict or post-error behavioral adjustments.Conclusions: Concurrently reduced conflict- and error-related activity in the anterior cingulate cortex along with reduced trial-to-trial adjustments in performance has not previously been reported in schizophrenia. The current results suggest that impaired conflict monitoring by the anterior cingulate cortex might play an important role in contributing to cognitive control deficits in patients with schizophrenia.