Impaired myocardial oxidative metabolism in the remote normal region in patients in the chronic phase of myocardial infarction and left ventricular remodeling
Impaired myocardial oxidative metabolism in the remote normal region in patients in the chronic phase of myocardial infarction and left ventricular remodeling
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DOI：
10.1007/s12350-008-9006-4
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发表时间：
2009-02-01
影响因子：
2.4
通讯作者：
Kimura, Genjiro
中科院分区：
文献类型：
--
作者：
Ohte, Nobuyuki;Narita, Hitomi;Kimura, Genjiro
背景资料。心肌梗死(MI)后左心室(LV)重构发生在远端正常区，并与心力衰竭密切相关。我们使用C-11-乙酸酯时间活动曲线的清除速率常数K-mono来评估15例既往前壁心肌梗死患者、8例既往下壁心肌梗死患者和10名年龄匹配的正常受试者的心肌耗氧量。超声心动图测定左心室收缩末期容量指数(ESVI)。前壁和下壁心肌梗死患者的LVESVI明显大于对照组。心率收缩压乘积在不同组之间没有差异。前壁心肌梗塞患者远端正常区K-MONO显著低于对照组(0.055+/-0.005 vs 0.065+/-0.008分)，P
Background. Left ventricular (LV) remodeling occurs in the remote normal region in the LVs after myocardial infarction (MI) and is closely involved in heart failure.Methods. We assessed myocardial oxygen consumption using a clearance rate constant K-mono for the time activity curves of C-11-acetate in 15 patients with a prior anterior wall MI, 8 with a prior inferior wall MI, and 10 age-matched normal control subjects. LV end-systolic volume index (ESVI) was determined by echocardiography.Results. The LVESVI was significantly greater in patients with an anterior and inferior MI than in control subjects. The heart rate systolic pressure product did not differ among the groups. K-mono in the remote normal region in patients with an anterior MI was significantly less than that in the corresponding area in control subjects (0.055 +/- 0.005 vs 0.065 +/- 0.008 min(-1), P