Biocompatibility of polyurethane-coated stents: tissue and vascular aspects.
Biocompatibility of polyurethane-coated stents: tissue and vascular aspects.
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DOI：
10.1002/(sici)1097-0304(199810)45:2
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发表时间：
1998-10
期刊：
影响因子：
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通讯作者：
E. Rechavia;F. Litvack;M. C. Fishbien;M. Nakamura;N. Eigler
中科院分区：
文献类型：
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作者：
E. Rechavia;F. Litvack;M. C. Fishbien;M. Nakamura;N. Eigler
为了评估聚氨酯涂层支架与未涂层支架引发的动脉损伤，将六个聚氨酯涂层支架和六个裸镍钛合金支架植入兔颈动脉中。放置支架后4周处死所有动物。通过组织学和形态测量分析评估切片。第 4 周时，涂覆和未涂覆的支架支柱均完全内皮化。支柱之间的空间显示出相对温和的增殖反应，其中一些切片显示支柱周围有新血管形成。聚氨酯涂层与炎症组织反应相关，包括淋巴细胞浸润和异物反应，并出现多核巨细胞。涂层和未涂层支架血管之间的管腔、内膜和内侧横截面积差异很小（分别为2.45+/-0.19 vs. 2.47+/-0.47 mm2、1.17+/-0.52 vs. 0.78+/-0.30 mm2、以及0.66+/-0.18 vs. 0.58+/-0.27 mm2）。在兔颈动脉模型中，与传统支架置入方法相比，聚氨酯涂层不影响血管内支架置入后新生内膜的增殖程度。然而，炎症组织反应可能表明这种稳定聚合物的内在生物相容性较低，因此它可能不是涂覆血管内装置的理想材料。
To assess the arterial injury triggered by polyurethane-coated vs. uncoated stents, six polyurethane-coated and six bare nitinol stents were implanted in rabbit carotid arteries. All animals were sacrificed 4 wk after stent placement. Sections were evaluated by histology and morphometric analysis. At 4 wk, both the coated and uncoated stent struts were entirely endothelialized. The spaces between the struts showed a relatively mild proliferative response, with a few sections demonstrating neovascularization around the struts. Polyurethane coating was associated with an inflammatory tissue response consisting of lymphocytic infiltration and foreign-body reaction, with the appearance of multinucleated giant cells. Lumen, intimal, and medial cross-sectional areas varied little between coated and uncoated stented vessels (2.45+/-0.19 vs. 2.47+/-0.47 mm2, 1.17+/-0.52 vs. 0.78+/-0.30 mm2, and 0.66+/-0.18 vs. 0.58+/-0.27 mm2, respectively). In the rabbit carotid artery model, polyurethane coating does not affect the degree of neointimal proliferation after endovascular stenting compared with the conventional stenting approach. However, the inflammatory tissue response may indicate a low intrinsic biocompatibility of this stable polymer, so that it may not be an ideal material for coating intravascular devices.