Towards Reaching the Target: Clinical Application of Mesenchymal Stem Cells for Diabetic Foot Ulcers
Towards Reaching the Target: Clinical Application of Mesenchymal Stem Cells for Diabetic Foot Ulcers
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DOI：
10.1089/rej.2013.1467
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发表时间：
2014-02-01
影响因子：
2.6
通讯作者：
Mohapatra, Prakash Chandra
中科院分区：
文献类型：
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作者：
Dash, Surjya Narayan;Dash, Nihar Ranjan;Mohapatra, Prakash Chandra
间充质干细胞（MSC）因其多谱系分化潜力而在非愈合性溃疡和组织再生的治疗应用方面具有巨大的前景。所递送的MSC可以迁移到损伤部位并通过刺激血管生成和促进血管再生来改善伤口愈合。2型糖尿病（T2DM）的发病率在全球范围内不断增加。它与周围神经病变和周围动脉闭塞性疾病（PAOD）有关，这些疾病使患者在轻微创伤后易发生不愈合的足部溃疡。糖尿病患者由于足部溃疡不愈合而截肢的比例很高，尽管开发了新的治疗方案，但这对社会来说是一个重大负担。近年来，干细胞移植已被认为是糖尿病足溃疡（DFU）的一种新的治疗选择。骨髓间充质干细胞的再生潜力已在实验和临床试验中得到证实。在这里，我们回顾了潜在的疗效和系统使用MSC治疗非愈合DFU，目前的进展，MSC输送系统，以及可能的选择，以提高干细胞的治疗潜力，伤口愈合。
Mesenchymal stem cells (MSCs) hold great promise for therapeutic application in non-healing ulcers and tissue regeneration because of their multi-lineage differentiation potential. MSCs delivered may migrate to the sites of injury and improve wound healing by stimulating angiogenesis and promoting revascularization. The incidence of type 2 diabetes mellitus (T2DM) is increasing worldwide. It is associated with peripheral neuropathy and peripheral arterial occlusive disease (PAOD), which predispose patients to develop non-healing foot ulcers following minor trauma. A high rate of amputation exists among diabetic patients due to non-healing foot ulcers, which are a significant burden for the society despite new therapeutic protocols developed. In recent years, stem cell transplantation has been considered as a new therapeutic option for diabetic foot ulcers (DFUs). The regeneration potential of MSCs has been demonstrated in the experimental and clinical trials. Here we review the potential efficacy and systematic use of MSCs for the treatment of non-healing DFUs, current advances, MSC delivery systems, and possible options to enhance the therapeutic potential of stem cell for wound healing.