Corticotropin-Releasing Factor (CRF) Neurocircuitry and Neuropharmacology in Alcohol Drinking.
Corticotropin-Releasing Factor (CRF) Neurocircuitry and Neuropharmacology in Alcohol Drinking.
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DOI：
10.1007/164_2017_86
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发表时间：
2018
影响因子：
--
通讯作者：
Gilpin NW
中科院分区：
文献类型：
--
作者：
Schreiber AL;Gilpin NW
饮酒在美国很普遍。在从非危险饮酒到危险饮酒和酒精使用障碍的转变过程中，大脑奖励和大脑应激系统中会发生神经适应。在过量饮酒和酒精依赖的动物模型中，一种备受关注的大脑信号系统是促肾上腺皮质激素释放因子（CRF）。 CRF 系统由 CRF、尿皮质素、CRF 结合蛋白和两种受体（CRF 1 型和 CRF 2 型）组成。这篇综述总结了急性、酗酒和慢性酒精如何失调下丘脑和下丘脑外大脑区域的 CRF 信号传导，以及这种失调如何导致酒精强化、过量饮酒、戒断期间负面影响症状和酒精复发的变化。此外，它还总结了在人类中检查 CRF-1 型受体拮抗剂的临床工作，并讨论了为什么大脑 CRF 系统在酒精研究中仍然具有相关性。
Alcohol use is pervasive in the United States. In the transition from non-hazardous drinking to hazardous drinking and alcohol use disorder, neuroadaptations occur within brain reward and brain stress systems. One brain signaling system that has received much attention in animal models of excessive alcohol drinking and alcohol dependence is corticotropin-releasing factor (CRF). The CRF system is composed of CRF, the urocortins, CRF-binding protein, and two receptors – CRF-type 1 and CRF-type 2. This review summarizes how acute, binge, and chronic alcohol dysregulate CRF signaling in hypothalamic and extra-hypothalamic brain regions, and how this dysregulation may contribute to changes in alcohol reinforcement, excessive alcohol consumption, symptoms of negative affect during withdrawal, and alcohol relapse. In addition, it summarizes clinical work examining CRF-type 1 receptor antagonists in humans and discusses why the brain CRF system is still relevant in alcohol research.