Seasonal changes in the response of fast and slow mammalian skeletal muscle fibers to zero potassium.
Seasonal changes in the response of fast and slow mammalian skeletal muscle fibers to zero potassium.
复制标题
快速和慢速哺乳动物骨骼肌纤维对零钾反应的季节性变化。
DOI：
10.1016/0024-3205(92)90292-w
复制
发表时间：
1992
期刊：
影响因子：
6.1
通讯作者：
McArdle,JJ
中科院分区：
文献类型：
--
作者：
Aiken,SP;McArdle,JJ
在研究大鼠骨骼肌纤维在零钾溶液中的静息膜电位（RMP）下降时，发现趾长伸肌（EDL）的反应存在季节性变化。在一月份，大多数EDL纤维超极化和一些去极化。纤维9月，大多数deepening; 5月记录的RMP的分布是双峰的，一些纤维超极化和一些去极化。来自比目鱼肌的纤维在零K+下不受季节影响。EDL纤维超极化的能力出现在产后第7周和第8周，并且取决于功能性神经的存在，因为去神经消除了这种反应。作为可能的解释这些发现，K+通道的失活和NA-K泵的抑制零K+进行了讨论。
While investigating the decline in resting membrane potential (RMP) of rat skeletal muscle fibers in zero potassium solution, we discovered that there is seasonal variation in the response of the extensor digitorum longus muscle (EDL). In January, most EDL fibers hyperpolarizing and some depolarizing. Fibers September, most depolarize; the distribution of RMPs recorded in May is bimodal, with some fibers hyperpolarizing and some depolarizing. Fibers from the soleus muscle depolarize in zero K+irrespective of the season. The ability of EDL fibers to hyperpolarize appears during the 7th and 8th weeks postpartum, and is dependent upon the presence of a functional nerve, since denervation abolished the response. As possible explanations for these findings, inactivation of K+-channels and inhibition of the NA-K pump by zero K+are discussed.