Rapid induction of protective tolerance to potential terrorist agents: a systematic review of low- and ultra-low dose research.
Rapid induction of protective tolerance to potential terrorist agents: a systematic review of low- and ultra-low dose research.
复制标题
快速诱导对潜在恐怖分子的保护性耐受：低剂量和超低剂量研究的系统回顾。
DOI：
10.1016/j.homp.2004.07.001
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发表时间：
2004
期刊：
影响因子：
--
通讯作者：
Jonas,WB
中科院分区：
文献类型：
--
作者：
Szeto,AL;Rollwagen,F;Jonas,WB
目的：系统综述低剂量和超低剂量毒素暴露预防和治疗生化威胁的相关文献。方法：收集13种高危化生化威胁中LD或ULD暴露防护或处理的实验室研究论文，采用预先确定的方法学标准，对数量和科学质量进行系统评价。结果：共筛选文献2600余篇。只有5项研究符合纳入标准，检查暴露于13种预先确定的生物和化学制剂的LD或LD的刺激和保护作用。这些研究的质量评价（QE）均高于平均水平，平均QE得分为最大值的70.6%。两篇质量尚可的文章报道了动物或人类暴露于低致病性毒物和超低致病性毒物的保护和治疗效果。结论：目前关于生物和化学战剂可能利用LD和LD毒素进行保护和治疗的研究很少。现有文献一般质量较好，表明快速诱导保护性耐受是一种可行的方法，但尚未得到充分研究。我们认为，需要进一步研究LD和LD毒性药物的诱导保护作用。
Objective: To systematically review the literature on the ability of low-dose (LD) and ultra-low-dose (ULD) toxin exposure to prevent and treat biological and chemical threats.Methods: Laboratory research articles on protection or treatment from LD or ULD exposure for the 13 high-risk chemical and biological warfare threats were collected and systematically evaluated for quantity and scientific quality using pre-defined methodological criteria.Results: Over 2600 articles were screened. Only five studies met the inclusion criteria examining stimulation and protective effects of LD- or ULD-exposures to the 13 pre-identified biological and chemical agents. The quality evaluation (QE) of these studies was above average with a mean QE score of 70.6% of maximum. Two articles of fair to good quality reported both protective and treatment efficacy from exposure of animals or humans to LD- and ULD-exposures to toxins of risk in biochemical warfare.Conclusion: There is little research on agents of biological and chemical warfare investigating the possible use of LD- and ULD-toxins for protection and treatment. The existing literature is generally of good quality and indicates that rapid induction of protective tolerance is a feasible but under-investigated approach to bioterrorist or biowarfare defense. In our opinion, further research into the role of induced protection with LD- and ULD-toxic agents is needed.