Potential Importance of Ozone in the Association Between Outdoor Air Pollution and Dry Eye Disease in South Korea
Potential Importance of Ozone in the Association Between Outdoor Air Pollution and Dry Eye Disease in South Korea
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DOI：
10.1001/jamaophthalmol.2016.0139
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发表时间：
2016-05-01
影响因子：
8.1
通讯作者：
Kim, Dong Hyun
中科院分区：
文献类型：
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作者：
Hwang, Sung Ha;Choi, Yoon-Hyeong;Kim, Dong Hyun
重要性空气污染是一个重要的公共卫生问题，眼表持续暴露于室外空气中的污染物。与空气污染相关的眼表异常被认为是干眼病 (DED) 的一种亚型。然而，迄今为止，还没有大规模研究评估包括多种空气污染物在内的空气污染与干眼症之间的关联。目的调查韩国人群中室外空气污染与干眼症之间的关联。设计、设置和参与者使用第五次韩国国家健康和营养检查调查中的 16824 名参与者的数据进行了一项基于人群的横断面研究，该研究于 2010 年 1 月 1 日至 2012 年 12 月 31 日进行。分析从9月1日开始 截至 2015 年 3 月 30 日。干眼病的定义是先前由眼科医生诊断或经常出现眼部疼痛和不适。室外空气污染测量（年平均湿度、空气动力学直径均为 0.05 的颗粒物）。 结论和相关性 较高的臭氧水平和较低的湿度水平与韩国人口的 DED 相关，而 PM10 水平与 DED 无关。
IMPORTANCE Air pollution is an important public health concern and the ocular surface is continuously exposed to pollutants in outdoor air. Ocular surface abnormalities related to air pollution are thought to be a subtype of dry eye disease (DED). However, to date, there is no large-scale study evaluating an association between air pollution and DED that includes multiple air pollutants.OBJECTIVE To investigate associations between outdoor air pollution and DED in a Korean population.DESIGN, SETTING, AND PARTICIPANTS A population-based cross-sectional study using data on 16 824 participants in the fifth Korea National Health and Nutrition Examination Survey was conducted from January 1, 2010, to December 31, 2012. Data analysis was conducted from September 1 to 30, 2015. Dry eye disease was defined as previously diagnosed by an ophthalmologist or the presence of frequent ocular pain and discomfort. Outdoor air pollution measurements (mean annual humidity, particulate matter with aerodynamic diameter .05 for each).CONCLUSIONS AND RELEVANCE Higher ozone levels and lower humidity levels were associated with DED in the Korean population, while PM10 level was not associated with DED.