Innate and adaptive immunologic functions of complement in the host response to Listeria monocytogenes infection.
Innate and adaptive immunologic functions of complement in the host response to Listeria monocytogenes infection.
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DOI：
10.1016/j.imbio.2016.07.004
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发表时间：
2016-12
期刊：
影响因子：
2.8
通讯作者：
Wetsel RA
中科院分区：
文献类型：
--
作者：
Calame DG;Mueller-Ortiz SL;Wetsel RA
单核细胞增生李斯特菌是引起食源性疾病相关死亡的主要原因，近年来由于几次重大爆发而引起了相当大的关注。它也是研究细胞内病原体的模式生物。由于这些原因，宿主对L.单核细胞增多症一直是研究的主题。一个有效的先天性和适应性免疫反应是遏制和清除L。单核细胞增多症。然而，这种反应的某些元素，如1型干扰素，可能对宿主有害。最近的研究揭示了补体系统在这一过程中的新功能，补体系统是先天免疫的一个古老分支。本文综述了补体在宿主对L.单核细胞增多症
Listeria monocytogenes is a leading cause of foodborne-illness associated mortality that has attracted considerable attention in recent years due to several significant outbreaks. It has also served as a model organism for the study of intracellular pathogens. For these reasons the host response to L. monocytogenes has long been the subject of investigation. A potent innate and adaptive immune response is required for containment and clearance of L. monocytogenes. However, some elements of this response, such as type 1 interferons, can be detrimental to the host. Recent studies have revealed novel functions for the complement system, an ancient arm of innate immunity, in this process. Here we review the role of complement in the host response to L. monocytogenes.
DOI：
10.1084/jem.163.1.54
发表时间：
1986-01-01
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Lee SH;Crocker P;Gordon S
通讯作者：
Gordon S