The Morphological Changes in the Capillary Architecture of the Tibial Nerve Associated with Spontaneous Aging and Aerobic Exercise Intervention during Aging in Rats.
The Morphological Changes in the Capillary Architecture of the Tibial Nerve Associated with Spontaneous Aging and Aerobic Exercise Intervention during Aging in Rats.
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DOI：
10.1589/jpts.26.263
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发表时间：
2014-02
影响因子：
--
通讯作者：
Fujino H
中科院分区：
文献类型：
--
作者：
Sakita M;Murakami S;Fujino H
【目的】与衰老相关的周围神经退化与毛细血管代谢相互作用失效有关。本研究的目的是在形态学上研究自发衰老和有氧运动干预下大鼠胫骨神经毛细血管结构的年龄相关变化。[研究对象]雄性Sprague-Dawley大鼠（n=15）。[方法]将大鼠分为对照组（Cont, n=5）、老年组（Elder, n=5）和老年有氧运动组（Elder+Ex, n=5）。从96周龄开始，Elder+Ex组在跑步机上进行10周的低强度有氧训练。采用共聚焦激光扫描显微镜三维图像比较Cont组（20周龄）、Elder组（106周龄）和Elder+Ex组胫骨神经毛细血管直径、横截面积和微血管分支数量。[结果]老龄组毛细血管直径、横截面积、微血管分支数均明显小于对照组和老龄+Ex组。[结论]提示周围神经毛细血管随自然衰老而退化，低强度有氧运动可促进血管生成，保护毛细血管免受氧化应激。
[Purpose] Peripheral nerve degradation associated with aging is linked to failure of interactions in capillary metabolism. The aim of this study was to morphologically investigate the age-related changes in the capillary architecture of the tibial nerve in spontaneous aging and with aerobic exercise intervention in rats. [Subjects] Male Sprague-Dawley rats (n=15) were used in the present study. [Methods] The rats were divided into control (Cont, n=5), elderly (Elder, n=5), and elderly with aerobic exercise (Elder+Ex, n=5) groups. Aerobic training of low intensity was performed for 10 weeks using a treadmill starting at 96 weeks of age by the Elder+Ex group. The capillary diameter, cross-sectional area and number of microvascular ramifications in the tibial nerve were compared among the Cont (20-week-old), Elder (106-week-old) and Elder+Ex groups using three-dimensional images gained from confocal laser scanning microscopy. [Results] The capillary diameter, cross-sectional area and number of microvascular ramifications in the Elder group were significantly smaller than those observed in the Cont and Elder+Ex groups. [Conclusion] These findings suggest that the capillaries in the peripheral nerve degrade with spontaneous aging and that aerobic exercise of low intensity promotes angiogenesis, and protects the capillary from oxidative stress.
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影响因子：
6.7
作者：
LORD, SR;WARD, JA
通讯作者：
WARD, JA
影响因子：
8.3
作者：
van Dijk, Ewoud J.;Prins, Niels D.;Breteler, Monique M. B.
通讯作者：
Breteler, Monique M. B.
影响因子：
3.3
作者：
Bejma, J;Ji, LL
通讯作者：
Ji, LL
影响因子：
6
作者：
BOUCHE, P;CATTELIN, F;SIMUNEK, P
通讯作者：
SIMUNEK, P
DOI：
10.1016/s0034-5687(01)00313-9
发表时间：
2001-11-15
期刊：
RESPIRATION PHYSIOLOGY
影响因子：
--
作者：
Wickens, AP
通讯作者：
Wickens, AP