Metabolomics application in maternal-fetal medicine.
Metabolomics application in maternal-fetal medicine.
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DOI：
10.1155/2013/720514
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发表时间：
2013
影响因子：
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通讯作者：
Ferrazzi E
中科院分区：
文献类型：
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作者：
Fanos V;Atzori L;Makarenko K;Melis GB;Ferrazzi E
代谢组学在母胎医学中仍然是一门“胚胎”科学。然而，人们对正常妊娠和复杂妊娠的代谢组学以及新生儿结局的兴趣越来越大。用于孕妇、胎儿和新生儿代谢组学研究的组织是羊水、血液、血浆、脐带血、胎盘、尿液和阴道分泌物。所有发表的论文都强调了这些组织中发现的生物标志物与胎儿畸形、早产、胎膜早破、妊娠期糖尿病、先兆子痫、新生儿窒息和缺氧缺血性脑病之间的强相关性。本综述的目的是总结和评论的原始数据，在相关出版的作品，以强调在不久的将来代谢组学在产科的临床潜力。
Metabolomics in maternal-fetal medicine is still an “embryonic” science. However, there is already an increasing interest in metabolome of normal and complicated pregnancies, and neonatal outcomes. Tissues used for metabolomics interrogations of pregnant women, fetuses and newborns are amniotic fluid, blood, plasma, cord blood, placenta, urine, and vaginal secretions. All published papers highlight the strong correlation between biomarkers found in these tissues and fetal malformations, preterm delivery, premature rupture of membranes, gestational diabetes mellitus, preeclampsia, neonatal asphyxia, and hypoxic-ischemic encephalopathy. The aim of this review is to summarize and comment on original data available in relevant published works in order to emphasize the clinical potential of metabolomics in obstetrics in the immediate future.