Three-dimensional computer-reconstructed image for studying cancer extension within the hypopharynx.
Three-dimensional computer-reconstructed image for studying cancer extension within the hypopharynx.
复制标题
用于研究下咽部癌症扩散的三维计算机重建图像。
DOI：
10.3109/00016489709113475
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发表时间：
1997
影响因子：
1.4
通讯作者：
T. Suzuki
中科院分区：
文献类型：
--
作者：
M. Nakayama;H. Takahashi;M. Okamoto;K. Yao;T. Makoshi;T. Suzuki
下咽癌是头颈部肿瘤中预后较差的一种。这是由于局部疾病的不可预测的扩展和远端转移的高比率。为了验证下咽癌的形态学行为，我们利用全咽咽食管切开术获得的喉部进行了全贴装水平连续切片。介绍了利用尼康Cosmozone 2SA软件对喉部进行高分辨率三维图像处理的技术。使用两个具有代表性的手术标本并重建三维图像。在这两个特殊病例中，肿瘤通过粘膜下淋巴管向上浸润，并在远高于主肿瘤的完整粘膜上皮下形成单独的子巢。三维图像增强了这些病例的形态学特征。这些病例也提示下咽癌手术中难以确定切除上限。三维重建是研究下咽癌形态学行为的一种重要方式。
Hypopharyngeal cancer is one of the head and neck cancers with poor prognosis. This is due to the unpredictable extension of the local disease and the high ratio of distant metastasis. To verify the morphological behavior of hypopharyngeal cancer, whole-mount horizontal serial sections were developed using the larynges obtained from total pharyngolaryngoesophagotomy. The technique of processing high-resolution three-dimensional (3D) images of the larynges using Nikon Cosmozone 2SA software is presented. Two representative surgical specimens were used and 3D images reconstructed. In these two particular cases, the cancer infiltrated superiorly through submucosal lymphatic ducts and formed separate daughter nests under the intact mucosal epithelium far above the main tumor. 3D images enhanced the morphological features of these cases. These cases also suggested the difficulty of defining the upper resecting limit in the operation of hypopharyngeal cancer. 3D reconstruction is and will be a crucial modality for studying the morphological behavior of hypopharyngeal cancer.