ANTIBODY TO HEPATITIS B CORE ANTIGEN - SENSITIVE INDICATOR OF HEPATITIS B VIRUS REPLICATION
ANTIBODY TO HEPATITIS B CORE ANTIGEN - SENSITIVE INDICATOR OF HEPATITIS B VIRUS REPLICATION
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DOI：
10.1056/nejm197406132902402
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发表时间：
1974-01-01
影响因子：
158.5
通讯作者：
BARKER, LF
中科院分区：
文献类型：
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作者：
HOOFNAGLE, JH;GERETY, RJ;BARKER, LF
与病毒性肝炎B型相关的抗原-抗体系统有两种：B型肝炎表面抗原（HBsAg）和抗体（抗-HB）以及最近表征的B型肝炎核心抗原（HBcAg）和抗体（抗-HBc）。研究了几个人群是否存在HBsAg、抗-HBs和抗-HBc。在1%的HBsAg阴性志愿献血者、98%的HBsAg阳性献血者和病毒疫苗正常接种者以及100%的慢性HBsAg携带者中发现了抗-HBc。在16例输血后肝炎患者中，10例抗-HBc阳性，3例HBsAg阳性，3例抗-HBs阳性。其余6名受牵连的供体在所有三项检测中均为阴性。这些数据与以下假设相一致，即HBcAg抗体检测可能是持续病毒复制的敏感指标，即使在HBsAg低于可检测量的情况下也是如此。（《新英格兰医学杂志》290：1336-1340，1974）
Two antigen-antibody systems are associated with viral hepatitis, Type B: the hepatitis B surface antigen (HBsAg) and antibody (anti-HBsand the recently characterized hepatitis B core antigen (HBcAg) and antibody (anti-HBc). Several populations were studied for the presence of HBsAg, anti-HBsand anti-HBc. Anti-HBcwas found in 1 per cent of volunteer HBsAg-negative blood donors, in 98 per cent of HBsAg-positive blood donors and normal recipients of viral vaccines, and in 100 per cent of chronic HBsAg carriers. Among 16 blood donors implicated in cases of post-transfusion hepatitis, 10 were positive for anti-HBc, among whom three were positive for HBsAg and three positive for anti-HBs. The remaining six implicated donors were negative by all three tests. These data are compatible with the hypothesis that a test for antibody to HBcAg may be a sensitive indicator of persistent viral replication even when subdetectable amounts of HBsAg are circulated. (N Engl J Med 290:1336–1340, 1974)