Form IV of carbamazepine
Form IV of carbamazepine
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DOI：
10.1002/jps.10093
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发表时间：
2002-04-01
影响因子：
3.8
通讯作者：
Matzger, AJ
中科院分区：
文献类型：
--
作者：
Lang, MD;Kampf, JW;Matzger, AJ
已发现卡马西平结晶为在室温下稳定的新多晶型物。我们报道了这种C中心单斜晶系的晶体结构（空间群C2/c，晶胞参数：a = 26.609，B = 6.9269，c = 13.957，β = 109.702），它由具有反配置的氢键二聚体组成。这是卡马西平的第三个修改，已被晶体学表征，第四个细胞参数已被确定。因此，它被指定为卡马西平的IV型。各种多晶型物之间的包装的差异进行了讨论。(C)2002 Wiley-Liss，Inc.
Carbamazepine has been found to crystallize as a new polymorph that is stable at room temperature. We report the crystal structure of this C-centered monoclinic form (space group C2/c, cell parameters: a = 26.609, b = 6.9269, c = 13.957, beta = 109.702), which consists of hydrogen bonded dimers with an anti-disposition. This represents the third modification of carbamazepine that has been crystallographically characterized, and the fourth for which cell parameters have been determined. Thus, it is designated as form IV of carbamazepine. Differences between the packing of the various polymorphs are discussed. (C) 2002 Wiley-Liss, Inc.