Nucleus accumbens response to rewards and testosterone levels are related to alcohol use in adolescents and young adults
Nucleus accumbens response to rewards and testosterone levels are related to alcohol use in adolescents and young adults
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DOI：
10.1016/j.dcn.2015.12.014
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发表时间：
2016-02-01
影响因子：
4.7
通讯作者：
Crone, Eveline A.
中科院分区：
文献类型：
--
作者：
Braams, Barbara R.;Peper, Jiska S.;Crone, Eveline A.
在青少年时期，冒险行为通常会增加，例如，酒精消费的增加。之前的研究已经证明了睾丸激素和酒精消费之间的联系，以及睾丸激素和对奖励的神经反应之间的联系。然而，迄今为止还没有研究测试睾丸激素水平和对奖励的神经反应如何与饮酒的个体差异相关并预测饮酒的个体差异。目前的研究旨在通过评估青少年（12-17岁）和年轻人（18-26岁）的酒精使用，睾丸激素水平和对奖励的神经反应来调查这一点。参与者被测量了两次，两次测试之间间隔两年。横断面分析表明，在第二个时间点，更高的神经活动的奖励，但不是睾酮水平，解释了显着的差异以上的年龄报告饮酒。预测分析表明，在第一时间点较高的睾酮水平，但不是神经活动的奖励在第一时间点，预测更多的酒精使用在第二时间点。这些结果表明，对奖励的神经反应与当前的饮酒量相关，睾酮水平可以预测未来的饮酒量。这些结果被解释的背景下，青少年发展的轨迹模型。(C)2015作者由Elsevier Ltd.发布。这是CC BY-NC-ND许可证下的开放获取文章（tittp：//creativecommons/org/licenses/by-nc-nd/4.0/）。
During adolescence there is a normative increase in risk-taking behavior, which is reflected in, for example, increases in alcohol consumption. Prior research has demonstrated a link between testosterone and alcohol consumption, and between testosterone and neural responses to rewards. Yet, no study to date tested how testosterone levels and neural responses to rewards relate to and predict individual differences in alcohol use. The current study aimed to investigate this by assessing alcohol use, testosterone levels and neural responses to rewards in adolescents (12-17 years old) and young adults (18-26 years old). Participants were measured twice with a two-year interval between testing sessions. Cross-sectional analysis showed that at the second time point higher neural activity to rewards, but not testosterone levels, explained significant variance above age in reported alcohol use. Predictive analyses showed that, higher testosterone level at the first time point, but not neural activity to rewards at the first time point, was predictive of more alcohol use at the second time point. These results suggest that neural responses to rewards are correlated with current alcohol consumption, and that testosterone level is predictive of future alcohol consumption. These results are interpreted in the context of trajectory models of adolescent development. (C) 2015 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (tittp://creativecommons/org/licenses/by-nc-nd/4.0/).