A protein farnesyl transferase involved in abscisic acid signal transduction in Arabidopsis
A protein farnesyl transferase involved in abscisic acid signal transduction in Arabidopsis
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DOI：
10.1126/science.273.5279.1239
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发表时间：
1996-08-30
期刊：
影响因子：
56.9
通讯作者：
McCourt, P
中科院分区：
文献类型：
--
作者：
Cutler, S;Ghassemian, M;McCourt, P
激素脱落酸(ABA)调节高等植物的各种发育过程和对环境胁迫的反应。拟南芥中对外源ABA具有增强反应的一组突变，称为ERA，包括ERA1基因的突变，该基因编码蛋白质法尼基转移酶的贝塔亚基。在酵母和哺乳动物系统中，法尼基转移酶修饰几种信号转导蛋白以定位膜。ERA1突变体表明，ABA敏感性的负调控因子必须由法尼基转移酶作用才能发挥作用。
The hormone abscisic acid (ABA) modulates a variety of developmental processes and responses to environmental stress in higher plants. A collection of mutations, designated era, in Arabidopsis thaliana that confer an enhanced response to exogenous ABA includes mutations in the Era1 gene, which encodes the beta subunit of a protein farnesyl transferase. In yeast and mammalian systems, farnesyl transferases modify several signal transduction proteins for membrane localization. The era1 mutants suggest that a negative regulator of ABA sensitivity must be acted on by a farnesyl transferase to function.