Infant leukemia and parental infertility or its treatment: a Children's Oncology Group report
Infant leukemia and parental infertility or its treatment: a Children's Oncology Group report
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DOI：
10.1093/humrep/deq090
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发表时间：
2010-06-01
影响因子：
6.1
通讯作者：
Ross, Julie A.
中科院分区：
文献类型：
--
作者：
Puumala, Susan E.;Spector, Logan G.;Ross, Julie A.
背景：对婴儿白血病的潜在危险因素了解甚少。由于诊断时的年龄非常小，因此怀疑在围产期发生接触。父母不孕不育和不孕不育的治疗已经研究了一般儿童癌症，但很少在个别癌症亚型。方法：通过儿童肿瘤组对1996年1月至2006年12月诊断的婴幼儿白血病病例进行病例对照研究，通过随机数字拨号和出生证明追踪选择对照组。对产妇进行电话访谈，以获得有关不孕症、不孕症治疗和人口因素的信息。所有病例以及由混合谱系白血病（MLL）易位状态和白血病亚型定义的亚组进行了检查。采用多元逻辑回归模型进行统计分析。结果：不孕症及其治疗与合并婴儿白血病无显著相关性。在亚组分析中，与尝试分娩1年的妇女相比，未尝试分娩的妇女所生的儿童患MLL -白血病的风险显著增加，所有类型合并[比值比（OR） 1.62, 95%可信区间（CI） 1.01-2.59]和急性淋巴细胞白血病（OR 2.50, 95% CI 1.36-4.61）。结论：父母不育或不育治疗与婴儿白血病无正相关。虽然这是迄今为止规模最大的研究，但选择和回忆偏差都可能影响结果。然而，对于婴儿白血病，我们可以潜在地排除与父母不育或其治疗相关的风险大幅增加的可能性。
Background: Little is known about the potential risk factors for infant leukemia. With its very young age at diagnosis, exposures occurring in the perinatal period are suspected. Parental infertility and infertility treatment have been studied with regard to childhood cancer in general, but rarely in individual cancer subtypes.Methods: A case-control study of infant leukemia was conducted through the Children's Oncology Group, including cases diagnosed from January 1996 to December 2006 and controls selected through random digit dialing and birth certificate tracing. Maternal phone interviews were conducted to obtain information about infertility, infertility treatment and demographic factors. All cases as well as subgroups defined by mixed lineage leukemia (MLL) translocation status and leukemia subtype were examined. Statistical analysis was performed using multivariate logistic regression models.Results: No significant associations between infertility or its treatment and combined infant leukemia were found. In subgroup analyses, there was a significant increase in the risk of MLL - leukemia for children born to women not trying to eive compared with those trying for,1 year for all types combined [odds ratio (OR) 1.62, 95% confidence interval (CI) 1.01-2.59] and for acute lymphoblastic leukemia (OR 2.50, 95% CI 1.36-4.61).Conclusions: There were no positive associations between parental infertility or infertility treatment and infant leukemia. While this is the largest study to date, both selection and recall bias may have impacted the results. However, for infant leukemia, we can potentially rule out large increases in risk associated with parental infertility or its treatment.